PI3K/Akt/mTOR

CAS号：1032568-63-0

品名：Copanlisib2-amino-N-[7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide

中文别名：Copanlisib

英文别名：BAY80-6946;2-Amino-N.N-diaethyl-toluolsulfonamid-(4);2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide;2-amino-toluene-4-sulfonicaciddiethylamide;2-Amino-toluol-4-sulfonsaeure-diaethylamid;

分子式：C23H28N8O4

分子量：480.52

精确质量：480.223

Psa：146.23

密度：1.5±0.1g/cm3

折射率：1.722

储存条件：-20℃

简介：Copanlisib(BAY80-6946),developedbyBayer,isaselectiveClassIphosphoinositide3-kinaseinhibitorwhichhasshownpromiseinPhaseI/IIclinicaltrialsforthetreatmentofnon-Hodgkinlymphomaandchroniclymphocyticleukemia.

PI3K/Akt/mTOR

CAS号：1173204-81-3

品名：PKI-402;1-[4-[3-乙基-7-(吗啉-4-基)-3H-[1,2,3]三唑并[4,5-d]嘧啶-5-基]苯基]-3-[4-[(4-甲基哌嗪-1-基)羰基]苯基]脲PKI-402

中文别名：PKI-402;1-[4-[3-乙基-7-(吗啉-4-基)-3H-[1,2,3]三唑并[4,5-d]嘧啶-5-基]苯基]-3-[4-[(4-甲基哌嗪-1-基)羰基]苯基]脲

英文别名：1-[4-(3-ethyl-7-morpholin-4-yltriazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]urea;1-[4-(3-ethyl-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl]-3-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea;

分子式：C29H34N10O3

分子量：570.645

精确质量：570.282

Psa：133.64

密度：

储存条件：at -20ºC 2 years

简介：PKI402isapotentpan-PI3K/mTORdualinhibitorandapotentialantitumordrug.

PI3K/Akt/mTOR

CAS号：1222998-36-8

品名：N-3-吡啶-4-[[3-[[5-(三氟甲基)-2-吡啶]氧基]苯基]甲基]-1-哌啶羧酰胺Torin-1

中文别名：N-3-吡啶-4-[[3-[[5-(三氟甲基)-2-吡啶]氧基]苯基]甲基]-1-哌啶羧酰胺

英文别名：1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one;1-[4-(4-propanoylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-9-quinolin-3-ylbenzo[h][1,6]naphthyridin-2-one;

分子式：C35H28F3N5O2

分子量：607.624

精确质量：607.22

Psa：71.33

密度：1.362

简介：Torin1isapotentandselectivemTORinhibitor(IC50=2-10nMformTORC1andmTORC2).Displays200-foldselectivityformTORoverDNA-PK,ATMandhVps34.

PI3K/Akt/mTOR

CAS号：663619-89-4

品名：7-甲基-2-(吗啉-4-基)-9-[1-(苯氨基)乙基]吡啶并[1,2-a]嘧啶-4-酮9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one

中文别名：7-甲基-2-(吗啉-4-基)-9-[1-(苯氨基)乙基]吡啶并[1,2-a]嘧啶-4-酮

英文别名：TGX221,TGX-221;7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one;7-methyl-2-morpholino-9-(1-(phenylamino)ethyl)-4H-pyrido[1,2-a]pyrimidin-4-one;TGX-221;(+/-)-7-methyl-2-morpholin-4-yl-9-(1-phenylaminoethyl)pyrido[1,2-a]pyrimidin-4-one;

分子式：C21H24N4O2

分子量：364.441

精确质量：364.19

Psa：58.87

MDL号：MFCD11113209

密度：1.259 g/cm3

沸点：557.293ºC at 760 mmHg

简介：TGX-221isapotent,selective,andcellpermeableinhibitorofPhosphatidylinositol3-kinase(PI3K)p110β.

PI3K/Akt/mTOR

CAS号：35943-35-2

品名：曲西立滨triciribine

中文别名：曲西瑞宾;1,5-二氢-5-甲基-1-BETA-D-呋喃核糖基-1,4,5,6,8-五氮杂苊-3-胺;

英文别名：API-2Akt/PKBSignalingInhibitor-2InhibitorV;1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine;Triciribine;

分子式：C13H16N6O4

分子量：320.304

精确质量：320.123

Psa：144.47

MDL号：MFCD28142766

密度：2.02g/cm3

沸点：718.5ºC at 760mmHg

闪点：388.3ºC

折射率：1.928

简介：Triciribineisanantitumortricyclicnucleoside.Triciribineactsasapotent,small-moleculeinhibitorofAKTphosphorylationinsubjectswithsolidtumorscontiningactivatedAKT.TriciribineisalsoaselectiveinhibitorofHIV-1andHIV-2,includingstrainsknowntoberesistanttoAZTorTIBO.

PI3K/Akt/mTOR

CAS号：162635-04-3

品名：西罗莫司脂化物Temsirolimus

中文别名：替西罗莫司;西罗莫司;

英文别名：CCL-779;Rapamycin(42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate];[14C]-Temsirolimus;TeMsiroliMus(CCI-779,Torisel);TeMsiroliMus(~);rapaMycin42-esterwith3-hydroxy-2-(hydroxyMethyl)-2-Methylpropionicacid;42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate]rapamycin;TeMsiroliMus(Torisel);Rapamycin42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate;(1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate;

分子式：C56H87NO16

分子量：1030.29

精确质量：1029.6

Psa：241.96

UNII号：624KN6GM2T

密度：1.2g/cm3

沸点：1048.4ºC at 760mmHg

熔点：99-101ºC

闪点：587.8ºC

折射率：1.553

蒸汽压：0mmHg at 25°C

简介：Temsirolimus(CCI-779)isanintravenousdrugforthetreatmentofrenalcellcarcinoma(RCC),developedbyWyethPharmaceuticalsandapprovedbytheU.S.FoodandDrugAdministration(FDA)inlateMay2007,andwasalsoapprovedbytheEuropeanMedicinesAgency(EMEA)onNovember2007.ItisaderivativeandprodrugofsirolimusandissoldasTorisel.

PI3K/Akt/mTOR

CAS号：280744-09-4

品名：3-(2,4-二氯苯基)-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione

中文别名：3-(2,4-二氯苯基)-4-(1-甲基-1H-吲哚-3-基)-1H-吡咯-2,5-二酮

英文别名：3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;

分子式：C19H12Cl2N2O2

分子量：371.217

精确质量：370.028

Psa：51.1

MDL号：MFCD09753369

密度：1.47 g/cm3

沸点：598.1ºC at 760 mmHg

熔点：287-288.6ºC(lit.)

闪点：315.5ºC

折射率：1.701

储存条件：-20ºC

蒸汽压：2.88E-14mmHg at 25°C

安全说明：S26; S36

危险类别码：R36/37/38

海关编码：2933990090

危险品标志：Xi

信号词：Warning

危险性防范说明：P261; P305 + P351 + P338

危险标志：GHS07

危险性描述：H315; H319; H335

PI3K/Akt/mTOR

CAS号：1092351-67-1

品名：2-(4-氨基-1-异丙基-1H-吡唑并[3,4-D]嘧啶-3-基)-1H-吲哚-5-醇(2E)-2-(4-amino-1-propan-2-yl-2H-pyrazolo[3,4-d]pyrimidin-3-ylidene)indol-5-ol

中文别名：PP242;

英文别名：2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol;2-[4-Amino-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol;Torkinib;PP242;EX-7207;QCR-154;2-(4-Amino-1-isopropyl-1H-pyrazolo(3,4-d)pyrimidin-3-yl)-1H-indol-5-ol;CS-0247;UNII-H5669VNZ7V;

分子式：C16H16N6O

分子量：308.338

精确质量：308.139

Psa：105.64

MDL号：MFCD12196869

密度：1.557 g/cm3

沸点：642.045ºC at 760 mmHg

闪点：342.097ºC

简介：PP242isusedinleukemiatherapysuppressingmTORsignaling.

PI3K/Akt/mTOR

CAS号：371935-74-9

品名：N,N,N-三甲基-2-[(二甲氨基)甲酰氧基]苯铵甲磺酸盐3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol

中文别名：3-[4-(4-吗啉基吡啶并[3',2',4,5]呋喃并[3,2-D]嘧啶-2-基]苯酚盐酸盐;PI103盐酸盐;

英文别名：X6K;PI103;

分子式：C19H17ClN4O3

分子量：384.816

精确质量：384.099

Psa：84.51

MDL号：MFCD11983145

密度：1.409 g/cm3

沸点：520.25ºC at 760 mmHg

折射率：1.712

简介：PI103isadualinhbitorofClassIAphosphatidylinositol3-kinaseandmammaliantargetofrapaymycincomplex1(mTORC1),bothofwhichareinvolvedinpathwaysoftenactivatedinmyelogenousleukemia.PI103alsofunctionstoenhancetumourradiosensitivity.

PI3K/Akt/mTOR

CAS号：157716-52-4

品名：哌立福新perifosine

中文别名：(1,1-二甲基哌啶-1--4-基)十八烷基磷酸酯;

英文别名：Perifosine(KRX-0401);(1,1-dimethylpiperidin-1-ium-4-yl)octadecylphosphate;Piperidinium(4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl;1,1-Dimethylpiperidin-1-ium-4-yloctadecylphosphate;

分子式：C25H52NO4P

分子量：461.658

精确质量：461.363

Psa：68.4

MDL号：MFCD00927554

密度：

熔点：271-272°(dec)

储存条件：?20°C

海关编码：2933399090

简介：Perifosine(alsoKRX-0401)isadrugcandidatebeingdevelopedforavarietyofcancerindications.Itisanalkyl-phospholipidstructurallyrelatedtomiltefosine.ItactsasanAktinhibitorandaPI3Kinhibitor.ItwasbeingdevelopedbyKeryxBiopharmaceuticalswhohavelicenseditfromÆternaZentarisInc.

PI3K/Akt/mTOR

CAS号：742112-33-0

品名：2-氨基-N-[4-[5-(2-菲基)-3-(三氟甲基)-1H-吡唑-1-基]苯基]乙酰胺2-amino-N-[4-[5-phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]acetamide

中文别名：达努塞替;

英文别名：PDK1inhibitorAR-12;2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide;

分子式：C26H19F3N4O

分子量：460.45

精确质量：460.151

Psa：72.94

MDL号：MFCD12912272

密度：1.369g/cm3

沸点：683.017ºC at 760 mmHg

闪点：366.876ºC

折射率：1.649

简介：OSU-03012(AR-12)isacelecoxibderivativewithanticancerandanti-microbialactivity.Unlikecelecoxib,OSU-03012doesnotinhibitCOX,butinhibitsseveralotherimportantenzymesinsteadwhichmaybeusefulinthetreatmentofsomeformsofcancer,whilealsohavingantifungalactivityviadisruptionofphosphoinositide-dependentkinase-1activity.WhencombinedwithPDE5inhibitorssuchassildenafilortadalafil,OSU-03012wasfoundtoshowenhancedanti-tumour,antibioticandantiviralactivityagainstawidevarietyoforganisms,withthisactivitythoughttobemediatedviainhibitionofthechaperoneproteinBiP.

PI3K/Akt/mTOR

CAS号：944396-07-0

品名：布帕尼西Buparlisib

中文别名：5-[2,6-二(4-吗啉)-4-嘧啶]-4-(三氟甲基)-2-吡啶胺;5-[2,6-二(4-吗啉基)-4-嘧啶基]-4-(三氟甲基)-2-吡啶胺;

英文别名：5-(2,6-Dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine;BKM120;NVP-BKM120;

分子式：C18H21F3N6O2

分子量：410.394

精确质量：410.168

Psa：89.63

MDL号：MFCD18251596

密度：1.382

海关编码：2934999090

简介：NVP-BKM120isanovelanti-tumoractivecompoundthatisselectiveinthatitinhibitsspecificallyPI3kinaseactivatingcelldeathingliomacells.Gliomacellsbeingthosethatproliferatefromtumorsinthebrainorthespine.

PI3K/Akt/mTOR

CAS号：1245537-68-1

品名：NVP-BGT226;1-(3-三氟甲基-4-(哌嗪-1-基)苯基)-8-(6-甲氧基吡啶-3-基)-3-甲基-1H-咪唑并[4,5-c]喹啉-2(3H)-酮马来酸盐(Z)-but-2-enedioicacid,8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]imidazo[4,5-c]quinolin-2-one

中文别名：NVP-BGT226;1-(3-三氟甲基-4-(哌嗪-1-基)苯基)-8-(6-甲氧基吡啶-3-基)-3-甲基-1H-咪唑并[4,5-c]喹啉-2(3H)-酮马来酸盐

英文别名：UNII-4YG62LG876;BGT226maleatesalt;BGT226(NVP-BGT226);BGT226;NVP-BGT226;

分子式：C32H29F3N6O6

分子量：650.604

精确质量：650.21

Psa：151.81

MDL号：MFCD22124895

密度：

储存条件：-20℃

简介：BGT226isanovelphosphatidylinositol-3kinase/mammaliantargetofrapamycin(PI3K/mTOR)dualinhibitorwhichhasshowntobeeffectivewithgefitinibinepidermalgrowthfactorreceptor(EGFR)inhibitor-sensitivenon-smallcelllungcancer(NSCLC)therapy.

PI3K/Akt/mTOR

CAS号：1032350-13-2

品名：8-[4-(1-氨基环丁基)苯基]-9-苯基-1,2,4-三唑并[3,4-f][1,6]萘啶-3(2H)-酮二盐酸盐MK-2206

中文别名：8-[4-(1-氨基环丁基)苯基]-9-苯基-1,2,4-噻唑并[3,4-f][1,6]萘啶-3(2H)-酮双盐酸盐;

英文别名：MK-2206

分子式：C25H23Cl2N5O

分子量：480.389

精确质量：479.128

Psa：89.07

UNII号：Q34I3E28IO

密度：

简介：AZD6244andMK2206aretargetedsmall-moleculedrugsthatinhibitMEKandAKTresponses.ThecombinationofAZD6244andMK2206hasasignificantsynergisticeffectontumorgrowthinvitroandinvivoandleadstoincreasedsurvivalratesinmicebearinghighlyaggressivehumanlungtumors.Antitumoragents.

PI3K/Akt/mTOR

CAS号：881375-00-4

品名：1-​Piperazineacetamide,4-​ethyl-​N-​[4-​[2-​(4-​morpholinyl)​-​4-​oxo-​4H-​1-​benzopyran-​8-​yl]​-​1-​dibenzothienyl]​-

中文别名：1-​Piperazineacetamide,4-​ethyl-​N-​[4-​[2-​(4-​morpholinyl)​-​4-​oxo-​4H-​1-​benzopyran-​8-​yl]​-​1-​dibenzothienyl]​-

分子式：C33H34N4O4S

分子量：582.712

精确质量：582.23

Psa：106.5

密度：

简介：KU-0060648isadualinhibitorofDNA-PKandPI3Kα,PI3Kβ,PI3Kδ.

PI3K/Akt/mTOR

CAS号：159351-69-6

品名：依维莫司Everolimus

中文别名：42-O-(2-羟乙基)雷帕霉素;42-O-(2-羟乙基)纳巴霉素;

英文别名：42-O-(2-Hydroxyethyl)-rapamycin;SDZRAD;Certican;Zortress;Afinitor;RAD-001;Certica;CERTICAN(R);

分子式：C53H83NO14

分子量：958.224

精确质量：957.581

Psa：204.66

UNII号：9HW64Q8G6G

外观与性状：灰白色至淡黄色粉末

密度：1.18 g/cm3

沸点：998.7ºC at 760 mmHg

闪点：557.8ºC

折射率：1.548

储存条件：-20ºC

蒸汽压：0mmHg at 25°C

安全说明：S45

危险类别码：R48/25

危险品标志：T

简介：Everolimus(INN)(earliercodenameRAD001)isthe40-O-(2-hydroxyethyl)derivativeofsirolimusandworkssimilarlytosirolimusasaninhibitorofmammaliantargetofrapamycin(mTOR).

PI3K/Akt/mTOR

CAS号：648450-29-7

品名：替诺福韦AS605240,5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione

中文别名：5-(6-喹噁啉yl亚甲基)-2,4-噻唑烷二酮;5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮;

英文别名：AS605240,5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione

分子式：C12H7N3O2S

分子量：257.268

精确质量：257.026

Psa：97.25

UNII号：8GRW063UT7

密度：1.553g/cm3

折射率：1.792

储存条件：2-8ºC

安全说明：S26

危险类别码：R36/37/38

危险品标志：Xi

信号词：Warning

危险性防范说明：P261; P305 + P351 + P338

危险标志：GHS07

危险性描述：H315; H319; H335

简介：AS605240isapotentandselectivePI3Kγinhibitor.

PI3K/Akt/mTOR

CAS号：1009298-09-2

品名：[5-[2,4-二((3S)-3-甲基吗啉-4-基)吡啶并[2,3-d]嘧啶-7-基]-2-甲氧基苯基]甲醇(5-(2,4-Bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

中文别名：5-[2,4-双[(3S)-3-甲基-4-吗啉]吡啶并[2,3-d]嘧啶-7-基]-2-甲氧基苯甲醇;

英文别名：[5-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol;

分子式：C25H31N5O4

分子量：465.545

精确质量：465.238

Psa：93.07

UNII号：970JJ37FPW

密度：1.248

沸点：694.302ºC at 760 mmHg

闪点：373.701ºC

简介：Apotent,selective,andorallybioavailableATP-competitivemTORkinaseinhibitorwithanIC50of0.8nM.ItinhibitsthephosphorylationofmTORC1substratesp70S6Kand4E-BP1aswellasphosphorylationofthemTORC2substrateAKTanddownstreamproteins.Therapamycin-resistantT37/46phosphorylationsiteson4E-BP1werefullyinhibitedbyAZD8055,resultinginsignificantinhibitionofcap-dependenttranslation.Invitro,AZD8055potentlyinhibitsproliferationandinducesautophagyinH838andA549cells.Invivo,AZD8055inducesadose-dependentpharmacodynamiceffectonphosphorylatedS6andphosphorylatedAKTatplasmaconcentrationsleadingtotumorgrowthinhibition.