抗生素

CAS号：14930-96-2

品名：细胞松弛素BcytochalasinB

中文别名：细胞松弛素B;

英文别名：CYTOCHALASINB;CytochalasinB;

分子式：C29H37NO5

分子量：479.608

精确质量：479.267

Psa：95.86

RTECS号：RO0205000

BRN号：1096207

EINECS号：239-000-2

MDL号：MFCD00077704

PubChem号：24892890

外观与性状：粉末

密度：1.2 g/cm3

沸点：740.6ºC at 760 mmHg

熔点：218-223ºC

闪点：401.7ºC

折射率：1.596

储存条件：-20ºC

蒸汽压：4.98E-23mmHg at 25°C

安全说明：28-36/37-45

危险类别码：R26/27/28; R63

危险品运输编码：UN 1544 6

危险类别：6.1(a)

危险品标志：T+

简介：CytochalasinB,thenameofwhichcomesfromtheGreekcytos(cell)andchalasis(relaxation),isacell-permeablemycotoxin.ItwasfoundthatsubstoichimetricconcentrationsofcytochalasinB(CB)stronglyinhibitnetworkformationbyactinfilaments.Duetothis,itisoftenusedincytologicalresearch.Itinhibitscytoplasmicdivisionbyblockingtheformationofcontractilemicrofilaments.Itinhibitscellmovementandinducesnuclearextrusion.CytochalasinBshortensactinfilamentsbyblockingmonomeradditionatthefast-growingendofpolymers.CytochalasinBinhibitsglucosetransportandplateletaggregation.Itblocksadenosine-inducedapoptoticbodyformationwithoutaffectingactivationofendogenousADP-ribosylationinleukemiaHL-60cells.Itisalsousedincloningthroughnucleartransfer.HereenucleatedrecipientcellsaretreatedwithcytochalasinB.CytochalasinBmakesthecytoplasmoftheoocytesmorefluidandmakesitpossibletoaspiratethenucleargenomeoftheoocytewithinasmallvesicleofplasmamembraneintoamicro-needle.Thereby,theoocytegenomeisremovedfromtheoocyte,whilepreventingruptureoftheplasmamembrane.