CAS:14930-96-2
14930-96-2
CAS号：14930-96-2
品名：细胞松弛素BcytochalasinB
中文别名：细胞松弛素B;
英文别名：CYTOCHALASINB;CytochalasinB;
分子式：C29H37NO5
分子量：479.608
精确质量：479.267
Psa：95.86
RTECS号：RO0205000
BRN号：1096207
EINECS号：239-000-2
MDL号：MFCD00077704
PubChem号：24892890
外观与性状：粉末
密度：1.2 g/cm3
沸点：740.6ºC at 760 mmHg
熔点：218-223ºC
闪点：401.7ºC
折射率：1.596
储存条件：-20ºC
蒸汽压：4.98E-23mmHg at 25°C
安全说明：28-36/37-45
危险类别码：R26/27/28; R63
危险品运输编码：UN 1544 6
危险类别：6.1(a)
危险品标志：T+
简介：CytochalasinB,thenameofwhichcomesfromtheGreekcytos(cell)andchalasis(relaxation),isacell-permeablemycotoxin.ItwasfoundthatsubstoichimetricconcentrationsofcytochalasinB(CB)stronglyinhibitnetworkformationbyactinfilaments.Duetothis,itisoftenusedincytologicalresearch.Itinhibitscytoplasmicdivisionbyblockingtheformationofcontractilemicrofilaments.Itinhibitscellmovementandinducesnuclearextrusion.CytochalasinBshortensactinfilamentsbyblockingmonomeradditionatthefast-growingendofpolymers.CytochalasinBinhibitsglucosetransportandplateletaggregation.Itblocksadenosine-inducedapoptoticbodyformationwithoutaffectingactivationofendogenousADP-ribosylationinleukemiaHL-60cells.Itisalsousedincloningthroughnucleartransfer.HereenucleatedrecipientcellsaretreatedwithcytochalasinB.CytochalasinBmakesthecytoplasmoftheoocytesmorefluidandmakesitpossibletoaspiratethenucleargenomeoftheoocytewithinasmallvesicleofplasmamembraneintoamicro-needle.Thereby,theoocytegenomeisremovedfromtheoocyte,whilepreventingruptureoftheplasmamembrane.
抗生素
