细胞骨架信号

CAS号：908112-43-6

品名：SNX2112;2-[(反式-4-羟基环己基)氨基]-4-[4,5,6,7-四氢-6,6-二甲基-4-氧代-3-(三氟甲基)-1H-吲唑-1-基]苯甲酰胺PF-04928473

中文别名：SNX2112;2-[(反式-4-羟基环己基)氨基]-4-[4,5,6,7-四氢-6,6-二甲基-4-氧代-3-(三氟甲基)-1H-吲唑-1-基]苯甲酰胺

英文别名：4-[6,6-dimethyl-4-oxo-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-hydroxycyclohexyl)amino]benzamide;SNX-2112;4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((4-hydroxycyclohexyl)amino)benzamide;

分子式：C23H27F3N4O3

分子量：464.481

精确质量：464.204

Psa：110.24

MDL号：MFCD16038907

密度：1.5±0.1g/cm3

沸点：619.8±55.0°Cat760mmHg

熔点：265-266℃

闪点：328.6±31.5°C

折射率：1.638

储存条件：-20℃

蒸汽压：0.0±1.9mmHgat25°C

简介：SNX-2112isaselectiveheatshockprotein90(Hsp90)inhibitorwhichcanexertapotentanticanceractivity.StudiesdemonstatesthatSNX-2112canexhibitapotentanticanceractivityagainstB16melanomacellsbothinvitroandinvivo,byinhibitingcellproliferationandinducingcellcyclearrestandapoptosisinamechanismdependentonthedegredationofHsp90clientproteins.