G蛋白偶联受体&G蛋白

CAS号：162359-56-0

品名：盐酸芬戈莫德fingolimodhydrochloride

中文别名：芬戈莫德盐酸盐;2-氨基-2-[2-(4-正辛基苯基)乙基]丙烷-1,3-二醇盐酸盐;芬戈莫德(FTY-720);盐酸曲吡那敏;2-氨基-2-[2-(4-辛烷基苯基)乙基]-1,3-丙二醇盐酸盐;

英文别名：FTY720Hydrochloride;FingolimodHCl/FTY720;FingolimodHCl;FingolimodHydrochloride;2-Amino-2-(4-octylphenethyl)propane-1,3-diolhydrochloride;2-Amino-2-[2-(4-n-octylphenyl)ethyl]propane-1,3-diolHydrochloride;2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diolhydrochlorideFingolimodhydrochloride;

分子式：C19H34ClNO2

分子量：343.932

精确质量：343.228

Psa：66.48

MDL号：MFCD00939512

外观与性状：白色固体

密度：1.016g/cm3

沸点：479.5ºC at 760 mmHg

熔点：102-107ºC

闪点：243.8ºC

折射率：1.531

蒸汽压：5.28E-10mmHg at 25°C

海关编码：2922199090

信号词：Warning

危险性防范说明：P261; P273; P305 + P351 + P338

危险标志：GHS07

危险性描述：H315; H319; H335; H412

简介：FTY720isaderivativeofISP-1(myriocin),afungalmetaboliteoftheChineseherbIscariasinclariiaswellasastructuralanalogueofSphingosine.FTY720isanovelimmunemodulatorthatprolongsallografttransplantsurvivalinnumberourmodelsbyinhibitinglymphocyteemigrationfromlymphoidorgans.FTY720usreportedtobephosphorylatedbysphingosinekinasetoFTY720-P,whichhasbeenshowntopotentlystimulateGTPgSbindingactivityinS1P-transfectedCHOcells(EC50=210pM,4.9nM,4.3nM,and1nMforS1P1,S1P3,S1P4andS1P5,respectively).