CAS:162359-56-0
162359-56-0
CAS号：162359-56-0
品名：盐酸芬戈莫德fingolimodhydrochloride
中文别名：芬戈莫德盐酸盐;2-氨基-2-[2-(4-正辛基苯基)乙基]丙烷-1,3-二醇盐酸盐;芬戈莫德(FTY-720);盐酸曲吡那敏;2-氨基-2-[2-(4-辛烷基苯基)乙基]-1,3-丙二醇盐酸盐;
英文别名：FTY720Hydrochloride;FingolimodHCl/FTY720;FingolimodHCl;FingolimodHydrochloride;2-Amino-2-(4-octylphenethyl)propane-1,3-diolhydrochloride;2-Amino-2-[2-(4-n-octylphenyl)ethyl]propane-1,3-diolHydrochloride;2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diolhydrochlorideFingolimodhydrochloride;
分子式：C19H34ClNO2
分子量：343.932
精确质量：343.228
Psa：66.48
MDL号：MFCD00939512
外观与性状：白色固体
密度：1.016g/cm3
沸点：479.5ºC at 760 mmHg
熔点：102-107ºC
闪点：243.8ºC
折射率：1.531
蒸汽压：5.28E-10mmHg at 25°C
海关编码：2922199090
信号词：Warning
危险性防范说明：P261; P273; P305 + P351 + P338
危险标志：GHS07
危险性描述：H315; H319; H335; H412
简介：FTY720isaderivativeofISP-1(myriocin),afungalmetaboliteoftheChineseherbIscariasinclariiaswellasastructuralanalogueofSphingosine.FTY720isanovelimmunemodulatorthatprolongsallografttransplantsurvivalinnumberourmodelsbyinhibitinglymphocyteemigrationfromlymphoidorgans.FTY720usreportedtobephosphorylatedbysphingosinekinasetoFTY720-P,whichhasbeenshowntopotentlystimulateGTPgSbindingactivityinS1P-transfectedCHOcells(EC50=210pM,4.9nM,4.3nM,and1nMforS1P1,S1P3,S1P4andS1P5,respectively).
G蛋白偶联受体&G蛋白
