神经信号

CAS号：123441-03-2

品名：利凡斯的明rivastigmine

中文别名：利斯的明;N-乙基-N-甲基-氨基甲酸3-[(S)-1-(二甲氨基)乙基]苯酯;

英文别名：N-Ethyl-N-methylcarbamicacid3-[(1S)-1-(dimethylamino)ethyl]phenyl-ester;[3-[(1S)-1-(dimethylamino)ethyl]phenyl]N-ethyl-N-methylcarbamate;Rivastigmine;

分子式：C18H28N2O8

分子量：400.424

精确质量：400.185

Psa：147.84

UNII号：PKI06M3IW0

密度：1.038g/cm3

沸点：316.2ºC at 760mmHg

闪点：145ºC

折射率：1.518

蒸汽压：0.000416mmHg at 25°C

简介：Rivastigmine(soldunderthetradenameExelon)isaparasympathomimeticorcholinergicagentforthetreatmentofmildtomoderatedementiaoftheAlzheimer'stypeanddementiaduetoParkinson'sdisease.Thedrugcanbeadministeredorallyorviaatransdermalpatch;thelatterformreducestheprevalenceofsideeffects,whichtypicallyincludenauseaandvomiting.Thedrugiseliminatedthroughtheurine,andappearstohaverelativelyfewdrug-druginteractions.

细胞周期

CAS号：827022-32-2

品名：帕布昔利布盐酸盐Palbociclibhydrochloride

中文别名：盐酸帕布昔利布;6-乙酰基-8-环戊基-5-甲基-2-[[5-(哌嗪-1-基)吡啶-2-基]氨基]-8H-吡啶并[2,3-d]嘧啶-7-酮盐酸盐;

英文别名：PalbociclibHCl;6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one,hydrochloride;

分子式：C24H30ClN7O2

分子量：483.994

精确质量：483.215

Psa：105.04

MDL号：MFCD22420809

密度：

沸点：727ºC at 760 mmHg

闪点：393.5ºC

其他分子

CAS号：107724-20-9

品名：依普利酮eplerenone

中文别名：伊普利酮;9,11α-乙氧基-17-羟基-3-氧-17α-孕-4-烯-7α,21-二羧酸-γ-内甲酯;

英文别名：Elperenone;epoxymexrenone;Inspra;EplerenoneC24H3006;EPLERINONE;9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylicAcidγ-LactoneMethylEster;EPLERENONE;Epleremone;

分子式：C24H30O6

分子量：414.491

精确质量：414.204

Psa：82.2

UNII号：6995V82D0B

外观与性状：白色固体

密度：1.31g/cm3

沸点：597.9ºC at 760mmHg

熔点：241-243ºC

闪点：259.5ºC

折射率：1.587

蒸汽压：0mmHg at 25°C

简介：Eplerenone(INN)isasteroidalantimineralocorticoidofthespirolactonegroupthatisusedasanadjunctinthemanagementofchronicheartfailure.Itissimilartothediureticspironolactone,thoughitismuchmoreselectiveforthemineralocorticoidreceptorincomparison(i.e.,doesnotpossessanyantiandrogen,progestogen,glucocorticoid,orestrogeniceffects),andisspecificallymarketedforreducingcardiovascularriskinpatientsfollowingmyocardialinfarction.BymodifyingthealternativedrugSpironolactone,thenewdrugwasdevelopedinparttoavoidundesiredandrogenicsideeffectsinmalepatients.Eplerenoneisapotassium-sparingdiuretic,meaningthatithelpsthebodygetridofwaterbutstillkeeppotassium.

用途：具有对醛固酮受体选择性强、降压效果好，作用持久等特点，并可逆转或减轻醛固酮对心血管的许多不利影响。