CAS:107724-20-9
107724-20-9
CAS号：107724-20-9
品名：依普利酮eplerenone
中文别名：伊普利酮;9,11α-乙氧基-17-羟基-3-氧-17α-孕-4-烯-7α,21-二羧酸-γ-内甲酯;
英文别名：Elperenone;epoxymexrenone;Inspra;EplerenoneC24H3006;EPLERINONE;9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylicAcidγ-LactoneMethylEster;EPLERENONE;Epleremone;
分子式：C24H30O6
分子量：414.491
精确质量：414.204
Psa：82.2
UNII号：6995V82D0B
外观与性状：白色固体
密度：1.31g/cm3
沸点：597.9ºC at 760mmHg
熔点：241-243ºC
闪点：259.5ºC
折射率：1.587
蒸汽压：0mmHg at 25°C
简介：Eplerenone(INN)isasteroidalantimineralocorticoidofthespirolactonegroupthatisusedasanadjunctinthemanagementofchronicheartfailure.Itissimilartothediureticspironolactone,thoughitismuchmoreselectiveforthemineralocorticoidreceptorincomparison(i.e.,doesnotpossessanyantiandrogen,progestogen,glucocorticoid,orestrogeniceffects),andisspecificallymarketedforreducingcardiovascularriskinpatientsfollowingmyocardialinfarction.BymodifyingthealternativedrugSpironolactone,thenewdrugwasdevelopedinparttoavoidundesiredandrogenicsideeffectsinmalepatients.Eplerenoneisapotassium-sparingdiuretic,meaningthatithelpsthebodygetridofwaterbutstillkeeppotassium.
用途：具有对醛固酮受体选择性强、降压效果好，作用持久等特点，并可逆转或减轻醛固酮对心血管的许多不利影响。
其他分子
