特立氟胺 Teriflunomide 0.1g

CAS号：163451-81-8

品名：特立氟胺teriflunomide

中文别名：(Z)-2-氰基-3-羟基-N-(4-(三氟甲基)苯基)丁-2-烯酰胺;A771726;Aubagio;(2Z)-2-氰基-3-羟基-N-[4-(三氟甲基)苯基]丁-2-烯酰胺;

英文别名：(2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide;(Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide;Teriflunomide;

分子式：C12H9F3N2O2

分子量：270.207

精确质量：270.062

Psa：73.12

密度：1.4±0.1g/cm3

沸点：410.8±45.0°Cat760mmHg

闪点：202.3±28.7°C

折射率：1.552

储存条件：-20°C

蒸汽压：0.0±1.0mmHgat25°C

海关编码：2942000000

信号词：Warning

危险标志：GHS07

危险性描述：H302

简介：Teriflunomide(tradenameAubagio,marketedbySanofi)istheactivemetaboliteofleflunomide.TeriflunomidewasinvestigatedinthePhaseIIIclinicaltrialTEMSOasamedicationformultiplesclerosis(MS).ThestudywascompletedinJuly2010.2-yearresultswerepositive.However,thesubsequentTENEREhead-to-headcomparisontrialreportedthat\"althoughpermanentdiscontinuations[oftherapy]weresubstantiallylesscommonamongMSpatientswhoreceivedteriflunomidecomparedwithinterferonbeta-1a,relapsesweremorecommonwithteriflunomide.\"ThedrugwasapprovedbytheFDAonSeptember13,2012andintheEuropeanUniononAugust26,2013.