其他分子
CAS号：28395-03-1
品名：布美他尼bumetanide
中文别名：强力速效利尿剂;5-正丁氨基-4-苯氧基-3-氨基磺酰基苯甲酸;3-(氨基磺酰基)-5-(丁基氨基)-4-苯氧基苯甲酸;3-正丁胺基-4苯氧基-5-氨基磺酰苯甲酸;
英文别名：Bumetanide;Fordiuran;3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoicacid;3-(butylamino)-4-phenoxy-5-sulfamoylbenzoicacid;3-(aminosulfonyl)-5-(butylamino)-4-phenoxybenzoicacid;Bumetanida;Bumex;Bumetanidum;2-phenoxy-3-butylamino-5-carboxybenzenesulfonamide;3-(butylamino-)-4-phenoxy-5-sulfamoylbenzoicacid;[3H]-Bumetanide;Fontego;Burinex;3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoicacid;Lunetoron;Segurex;
分子式：C17H20N2O5S
分子量：364.416
精确质量：364.109
Psa：127.1
RTECS号：DG4910000
MDL号：MFCD00078949
外观与性状：结晶固体
密度：1.347g/cm3
沸点：571.2ºC at 760mmHg
熔点：230-2310C
闪点：299.3ºC
折射率：1.612
稳定性：Stable at normal temperatures and pressures.
储存条件：库房通风低温干燥
蒸汽压：6.89E-14mmHg at 25°C
WGK Germany：3
海关编码：2935009090
简介：Bumetanide(tradenamesBumexorBurinex)isaloopdiureticofthesulfamylcategorytotreatheartfailure.Itisoftenusedinpeopleinwhomhighdosesoffurosemideareineffective.ItismarketedbyHoffmann-LaRoche.Themaindifferencebetweenthetwosubstancesisinbioavailabilityandpharmacodynamicpotency.Furosemideisincompletelyabsorbedintheintestine(60%),andtherearesubstantialinter-andintraindividualdifferencesinbioavailability(range10-90%).Bumetanideisalmostcompletelyabsorbed(80%),andtheabsorptionisnotalteredwhenitistakenwithfood.Itissaidtobeamorepredictablediuretic,meaningthatthepredictableabsorptionisreflectedinamorepredictableeffect.
用途：利尿剂，对高血压，肾功能衰竭，急性药物毒物中毒等症有预防和治疗作用。
