CAS:128517-07-7
128517-07-7
CAS号：128517-07-7
品名：罗米地辛romidepsin
中文别名：FK228罗米地辛;
英文别名：Chromadax;Istodax;Romidepsin(FK228,depsipeptide);Romidepsin;FK-228;Depsipeptide;(1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone;
分子式：C24H36N4O6S2
分子量：540.696
精确质量：540.208
Psa：193.3
UNII号：CX3T89XQBK
密度：1.174g/cm3
沸点：942.8ºC at 760 mmHg
闪点：524ºC
折射率：1.529
蒸汽压：0mmHg at 25°C
简介：Romidepsin,alsoknownasIstodax,isananticanceragentusedincutaneousT-celllymphoma(CTCL)andotherperipheralT-celllymphomas(PTCLs).RomidepsinisanaturalproductobtainedfromthebacteriaChromobacteriumviolaceum,andworksbyblockingenzymesknownashistonedeacetylases,thusinducingapoptosis.Itissometimesreferredtoasdepsipeptide,aftertheclassofmoleculestowhichitbelongs.RomidepsinisbrandedandownedbyGloucesterPharmaceuticals,nowapartofCelgene.
细胞骨架信号
