CAS:104987-11-3
104987-11-3
CAS号：104987-11-3
品名：他克莫司Tacrolimus
中文别名：藤霉素;
英文别名：fujimycin;Prograf;Advagraf;Protopic;FK-506;3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,monohydrate;
分子式：C44H69NO12
分子量：804.018
精确质量：803.482
Psa：178.36
RTECS号：KD4201200
PubChem号：24724482
外观与性状：白色或灰白色结晶粉末
密度：1.19 g/cm3
沸点：871.7ºC at 760 mmHg
熔点：113-115°C
闪点：481ºC
折射率：1.549
储存条件：-20ºC
蒸汽压：1.73E-35mmHg at 25°C
安全说明：45-36-26
危险类别码：R25; R36/37/38
WGK Germany：3
危险品运输编码：UN 2811 6.1/PG 3
危险品标志：Xi; T
简介：Tacrolimus(alsoFK-506orfujimycin,tradenamesPrograf,Advagraf,Protopic)isanimmunosuppressivedrugusedmainlyafterallogeneicorgantransplanttolowertheriskoforganrejection.Itachievesthisbyinhibitingtheproductionofinterleukin-2,amoleculethatpromotesthedevelopmentandproliferationofTcells,whicharevitaltothebody'slearned(oradaptive)immuneresponse.TacrolimusisalsousedinthetreatmentofotherTcell-mediateddiseasessuchaseczema(forwhichitisappliedtotheskininamedicatedointment),severerefractoryuveitisafterbonemarrowtransplants,exacerbationsofminimalchangedisease,Kimura'sdisease,andtheskinconditionvitiligo.
用途：治疗肝脏或肾脏移植术后应用其他免疫抑制药物无法控制的移植物排斥反应。现已作为预防、治疗排斥反应以及自身免疫性肝炎的一线药物。
抗生素
