CAS:877399-52-5
877399-52-5
CAS号：877399-52-5
品名：克唑替尼Crizotinib
中文别名：克里唑替尼;克里唑啼尼;3-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺;3-[(R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(哌啶-4-基)-1H-吡唑-4-基]吡啶-2-胺;
英文别名：(R)-Crizotinib;Xalkori;3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine;
分子式：C21H22Cl2FN5O
分子量：450.337
精确质量：449.119
Psa：77.99
MDL号：MFCD12407409
密度：1.475g/cm3
沸点：599.177ºC at 760 mmHg
闪点：316.171ºC
折射率：1.673
海关编码：2933990090
信号词：Warning
危险性防范说明：P273; P280; P305 + P351 + P338
危险标志：GHS07, GHS08, GHS09
危险性描述：H317; H319; H341; H400
简介：Crizotinib(tradenameXalkori,Pfizer)isananti-cancerdrugactingasanALK(anaplasticlymphomakinase)andROS1(c-rosoncogene1)inhibitor,approvedfortreatmentofsomenon-smallcelllungcarcinoma(NSCLC)intheUSandsomeothercountries,andundergoingclinicaltrialstestingitssafetyandefficacyinanaplasticlargecelllymphoma,neuroblastoma,andotheradvancedsolidtumorsinbothadultsandchildren.
用途：抗肿瘤。
蛋白酪氨酸激酶
