CAS:1140909-48-3
1140909-48-3
CAS号：1140909-48-3
品名：卡博替尼苹果酸盐CabozantinibS-Malate
中文别名：苹果酸卡博替尼;
英文别名：cyclopropane-1,1-dicarboxylicacid[4-(6,7-dimethoxyquinoline-4-yloxy)phenyl]amide(4-fluoro-phenyl)amide(L)-malatesalt;Cabozantinibmalate(XL184);Cabozantinibmalate;Cabozantinibmalatesalt;UNII-DR7ST46X58;cyclopropane-1,1-dicarboxylicacid[4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide(4-fluoro-phenyl)-amideL-malate;N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide(L)malate;Cometriq;Cabozantinibs-malate[USAN];XL184;CabozantinibL-MalateSalt;N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide(L)-malatesalt;Cabozantinib(XL184);1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide,(2S)-2-hydroxybutanedioicacid;
分子式：C32H30FN3O10
分子量：635.593
精确质量：635.192
Psa：193.61
UNII号：DR7ST46X58
密度：
储存条件：室温，干燥，密封
简介：CabozantinibisasmallmoleculeC-Metmodulator.CabozantinibactsasapotentmultitargetedVEGFR2,Met,FLT3,Tie2,KitandRetinhibitorwithIC50of0.035,1.8,14.4,14.3and4.6nMforVEGFR2,Met,FLT3,Tie2andKit,respectively.Cabozantinibshowsdose-dependentinhibitionoftumorgrowthandtumorregression,associatedwithdisruptionofthetumorvasculatureandextensivetumorcellapoptosis.
蛋白酪氨酸激酶
