CAS:905854-02-6
905854-02-6
CAS号：905854-02-6
品名：(3R,4R)-3-(5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉)-4-(1H-吲哚)-2,5-吡咯烷二酮3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione
中文别名：祖师麻甲素.瑞香素;TIVANTINIBARQ-197;(3R,4R)-3-(5,6-二氢-4H-吡咯并[3,2,1-IJ]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮;
英文别名：Tivantinib/ARQ197/ARQ-197;(-)-3(R),4(R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione;Tivantinib(ARQ197);(-)-3(R),4(R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione,(-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione;(3R,4R)-3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-pyrrolidinedione;Tivantinib;(-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione;
分子式：C23H19N3O2
分子量：369.416
精确质量：369.148
Psa：66.89
UNII号：PJ4H73IL17
密度：1.5g/cm3
沸点：715.95ºC at 760 mmHg
闪点：386.793ºC
折射率：1.797
简介：Tivantinib(ARQ197;byArqule,Inc.)isanexperimentalanti-cancerdrug.ItisabisindolylmaleimidethatbindstothedephosphorylatedMETkinaseinvitro.TivantinibisbeingtestedclinicallyasahighlyselectiveMETinhibitor.However,themechanismofactionoftivantinibisstillunclear.;TivantinibdisplayscytotoxicactivityviamolecularmechanismsthatareindependentfromitsabilitytobindMET.
蛋白酪氨酸激酶
