CAS:356068-94-5
356068-94-5
CAS号：356068-94-5
品名：托西尼布Toceranib
中文别名：托西尼布
英文别名：5-(5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylicacid(2-pyrrolidin-1-yl-ethyl)-amide;5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide;5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide;
分子式：C22H25FN4O2
分子量：396.458
精确质量：396.196
Psa：77.23
MDL号：MFCD16038046
密度：
储存条件：-20C
简介：Toceranibisareceptortyrosinekinaseinhibitorandisusedinthetreatmentofcaninemastcelltumoralsocalledmastocytoma.Togetherwithmasitinib(Kinavet(US)/Masivet(EU/ROW)byABScience),toceranibistheonlydog-specificanti-cancerdrugapprovedbytheU.S.FoodandDrugAdministration.ItismarketedasPalladiaasitsphosphatesalt,toceranibphosphate(INN)byPfizer.ItwasdevelopedbySUGENasSU11654,asistercompoundtosunitinib,whichwaslaterapprovedforhumantherapies.Toceranibislikelytoactmostlythroughinhibitionofthekittyrosinekinase,thoughitmayalsohaveananti-angiogeniceffect.
蛋白酪氨酸激酶
