生物缓冲液

CAS号：26305-03-3

品名：胃酶抑素APepstatinA

中文别名：抑肽素;胃蛋白酶抑制剂;

英文别名：pepsininhibitors735a;peptistatinA;PEPSTATINASYNTHETIC;Isovalerylpepstatin;procidins735a;PepstainA;PEPSTATIN;pepstatineA;ahpatininc;IVA-VAL-VAL-STA-ALA-STA;

分子式：C34H63N5O9

分子量：685.892

精确质量：685.463

Psa：223.26

RTECS号：SC6155000

BRN号：2201362

EINECS号：247-600-0

MDL号：MFCD00060740

PubChem号：24898620

外观与性状：固体

密度：1.117 g/cm3

沸点：997.6ºC at 760 mmHg

熔点：233°C (dec.)(lit.)

闪点：557.1ºC

折射率：1.504

稳定性：Stable. Incompatible with strong bases, strong acids.

储存条件：2-8ºC

蒸汽压：0mmHg at 25°C

安全说明：S22-S24/25

WGK Germany：2

简介：Pepstatinisapotentinhibitorofaspartylproteases.Itisahexa-peptidecontainingtheunusualaminoacidstatine(Sta,(3S,4S)-4-amino-3-hydroxy-6-methylheptanoicacid),havingthesequenceIsovaleryl-Val-Val-Sta-Ala-Sta(Iva-Val-Val-Sta-Ala-Sta).ItwasoriginallyisolatedfromculturesofvariousspeciesofActinomycesduetoitsabilitytoinhibitpepsinatpicomolarconcentrations.PepstatinAiswellknowntobeaninhibitorofasparticproteinasessuchaspepsin,cathepsinsDandE.Exceptforitsroleasaproteinaseinhibitor,however,thepharmacologicalactionofpepstatinAuponcellsremainunclear.PepstatinAsuppressesreceptoractivatorofNF-κBligand(RANKL)–inducedosteoclastdifferentiation.PepstatinAsuppressestheformationofmultinuclearosteoclastsdose-dependently.Thisinhibitionoftheformationonlyaffectedosteoclastcells,i.e.,notosteoblast-likecells.Furthermore,pepstatinAalsosuppressesdifferentiationfrompre-osteoclastcellstomononuclearosteoclastcellsdose-dependently.ThisinhibitionseemstobeindependentoftheactivitiesofproteinasessuchascathepsinD,becausetheformationofosteoclastswasnotsuppressedwiththeconcentrationthatinhibitedtheactivityofcathepsinD.CellsignalinganalysisindicatedthatthephosphorylationofERKwasinhibitedinpepstatinA-treatedcells,whilethephosphorylationofIκBandAktshowedalmostnochange.Furthermore,pepstatinAdecreasedtheexpressionofnuclearfactorofactivatedTcellsc1(NFATc1).TheseresultssuggestthatpepstatinAsuppressesthedifferentiationofosteoclaststhroughtheblockadeofERKsignalingandtheinhibitionofNFATc1expression.

生物缓冲液

CAS号：2002-24-6

品名：乙醇胺盐酸盐2-aminoethanol,hydrochloride

中文别名：2-氨基乙醇盐酸盐;盐酸乙醇胺;2-羟基乙胺盐酸盐;

英文别名：MEAhydrochloride;Ethanolaminehydrochloride;EthanolamineHCl;N-(2-hydroxyethyl)-ammoniumchloride;2-Aminoethanolhydrochloride;2-hydroxyethylaminohydrochloride;ethan-1-ol-2-aminehydrochloride;monoethanolaminehydrochloride;2-HydroxyethylamineHydrochloride;Colaminehydrochloride;ethanolaminehydrochloride;Ethanol,2-amino-,hydrochloride;Ethanol,2-amino-,hydrochloride;MonoethanolamineHydrochloride;2-ethanolaminehydrochloride;Ethanolaminechloride;

分子式：C2H8ClNO

分子量：97.544

精确质量：97.0294

Psa：46.25

RTECS号：KJ6370000

BRN号：3542892

EINECS号：217-900-6

MDL号：MFCD00012892

PubChem号：24894620

密度：

沸点：170.9ºC at 760 mmHg

熔点：82-84°C(lit.)

闪点：93.3ºC

储存条件：Store at RT.

蒸汽压：0.458mmHg at 25°C

安全说明：S26; S36/37/39

危险类别码：R36/37/38

WGK Germany：1

海关编码：2923900090

危险品标志：Xi

生物缓冲液

CAS号：150-25-4

品名：N,N-二羟乙基甘氨酸N,N-bis(2-hydroxyethyl)glycine

中文别名：N,N-二-羟乙基甘氨酸;N,N-双(2-羟乙基)甘氨酸;N,N-二-羟乙基甘氨酸;二羟乙甘胺酸;N,N-双(2-羟乙基)甘氨酸(Bicine);二乙醇甘氨酸;N,N-二(2-羟乙基)甘氨酸;N-二（2-羟乙基）甘氨酸;

英文别名：N,N-Bis(2-hydroxyethyl)glycine,BICINE,PEGGridScreening;2-[bis(2-hydroxyethyl)amino]aceticacid;Diethylolglycine;N,N-Dihydroxyethylglycine;Bicine;BICINE[N,N-Di(2-hydroxyethyl)glycine];BICINEbuffer;Bicene;N,N-Di(2-hydroxyethyl)glycine;N,N-Di(2-hydroxyethyl)glycine[Good'sbuffercomponent;N,N-Bis(2-hydroxyethyl)glycine;Diethanolglycine;N,N-Bis(2-hydroxyethyl)glycine(Bicine);Glycine,N,N-bis(2-hydroxyethyl)-;Diethanolglycine;Dihydroxyethylglycine;

分子式：C6H13NO4

分子量：163.172

精确质量：163.084

Psa：81.0

RTECS号：MB9700000

BRN号：1769362

EINECS号：205-755-1

MDL号：MFCD00004295

PubChem号：24891738

外观与性状：白色结晶粉末

密度：1.05g/mLat 20°C

沸点：388.5ºC at 760mmHg

熔点：190°C (dec.)(lit.)

闪点：188.8ºC

稳定性：Stable at room temperature in closed containers under normal storage and handling conditions.

储存条件：2-8ºC

安全说明：S24/25

危险类别码：R20/21/22

WGK Germany：3

海关编码：29225000

危险品标志：Xn

简介：Bicineisanorganiccompoundusedasabufferingagent.ItisoneofGood'sbuffersandhasapKaof8.35at20°C.Itispreparedbythereactionofglycinewithethyleneoxide,followedbyhydrolysisoftheresultantlactone.

用途：在生化研究中用作缓冲剂

生物缓冲液

CAS号：103476-89-7

品名：亮抑酶肽Leupeptinhemisulfate

中文别名：亮抑蛋白酶肽;亮抑肽酶;

英文别名：Leupeptin,synthetic;LEUPEPTIN1/2H2SO4;Leupeptin,Microbial;AC-LEU-LEU-ARGININAL;AC-LEU-LEU-ARG-CHO;SynonymAcetyl-Leu-L;LEUPEPTINSULFATE;AC-LLR-CHO;

分子式：C20H38N6O4

分子量：426.554

精确质量：426.295

Psa：166.27

MDL号：MFCD00037012

PubChem号：24896328

外观与性状：白色固体

密度：

储存条件：-20ºC

安全说明：S22; S24/25; S36/37; S36

危险类别码：R20/21/22

WGK Germany：3

海关编码：29241900

危险品标志：Xn

信号词：Warning

危险性防范说明：P261; P264; P280; P302 + P352 + P312; P304 + P340 + P312; P501

危险标志：GHS07

危险性描述：H302 + H312 + H332