生物缓冲液

CAS号：26305-03-3

品名：胃酶抑素APepstatinA

中文别名：抑肽素;胃蛋白酶抑制剂;

英文别名：pepsininhibitors735a;peptistatinA;PEPSTATINASYNTHETIC;Isovalerylpepstatin;procidins735a;PepstainA;PEPSTATIN;pepstatineA;ahpatininc;IVA-VAL-VAL-STA-ALA-STA;

分子式：C34H63N5O9

分子量：685.892

精确质量：685.463

Psa：223.26

RTECS号：SC6155000

BRN号：2201362

EINECS号：247-600-0

MDL号：MFCD00060740

PubChem号：24898620

外观与性状：固体

密度：1.117 g/cm3

沸点：997.6ºC at 760 mmHg

熔点：233°C (dec.)(lit.)

闪点：557.1ºC

折射率：1.504

稳定性：Stable. Incompatible with strong bases, strong acids.

储存条件：2-8ºC

蒸汽压：0mmHg at 25°C

安全说明：S22-S24/25

WGK Germany：2

简介：Pepstatinisapotentinhibitorofaspartylproteases.Itisahexa-peptidecontainingtheunusualaminoacidstatine(Sta,(3S,4S)-4-amino-3-hydroxy-6-methylheptanoicacid),havingthesequenceIsovaleryl-Val-Val-Sta-Ala-Sta(Iva-Val-Val-Sta-Ala-Sta).ItwasoriginallyisolatedfromculturesofvariousspeciesofActinomycesduetoitsabilitytoinhibitpepsinatpicomolarconcentrations.PepstatinAiswellknowntobeaninhibitorofasparticproteinasessuchaspepsin,cathepsinsDandE.Exceptforitsroleasaproteinaseinhibitor,however,thepharmacologicalactionofpepstatinAuponcellsremainunclear.PepstatinAsuppressesreceptoractivatorofNF-κBligand(RANKL)–inducedosteoclastdifferentiation.PepstatinAsuppressestheformationofmultinuclearosteoclastsdose-dependently.Thisinhibitionoftheformationonlyaffectedosteoclastcells,i.e.,notosteoblast-likecells.Furthermore,pepstatinAalsosuppressesdifferentiationfrompre-osteoclastcellstomononuclearosteoclastcellsdose-dependently.ThisinhibitionseemstobeindependentoftheactivitiesofproteinasessuchascathepsinD,becausetheformationofosteoclastswasnotsuppressedwiththeconcentrationthatinhibitedtheactivityofcathepsinD.CellsignalinganalysisindicatedthatthephosphorylationofERKwasinhibitedinpepstatinA-treatedcells,whilethephosphorylationofIκBandAktshowedalmostnochange.Furthermore,pepstatinAdecreasedtheexpressionofnuclearfactorofactivatedTcellsc1(NFATc1).TheseresultssuggestthatpepstatinAsuppressesthedifferentiationofosteoclaststhroughtheblockadeofERKsignalingandtheinhibitionofNFATc1expression.

生物缓冲液

CAS号：66701-25-5

品名：N-(反式-环氧丁二酰基)-L-亮氨酸-4-胍基丁基酰胺E64

中文别名：反-环氧丁二酰基-L-亮氨酰胺基(4-胍基)丁烷;E-64蛋白酶抑制剂;

英文别名：thiolproteaseinhibitor;E-64,L-trans-Epoxysuccinyl-Leu-agMatine;(L-3-trans-carboxyoxiran-2-carbonyl)-L-leucyl-agmatin;L-TRANS-EPOXYSUCCINYL-LEU-AGMATINE;L-TRANS-EPOXYSUCCINYL-LEU-4-GUANIDINOBUTYLAMIDE;e64(proteinaseinhibitor);E-64PROTEASEINHIBITOR;EPOXYSUCCINYL-L-LEUCYLAMIDO-(4-GUANIDINO)BUTANE;E-64ProteaseInhibitor;proteinaseinhibitore64;E-64HEMIHYDRATE;E-64;

分子式：C15H27N5O5

分子量：357.405

精确质量：357.201

Psa：169.93

RTECS号：RR0390000

UNII号：R76F7856MV

外观与性状：白色固体

密度：1.44 g/cm3

熔点：182ºC

折射率：1.617

储存条件：2-8ºC

安全说明：S22; S24/25

危险类别码：R68/20/22

WGK Germany：3

信号词：Warning

危险性防范说明：P260; P264; P270; P308 + P311; P501

危险标志：GHS08

危险性描述：H371

简介：E-64isanepoxidewhichcanirreversiblyinhibitawiderangeofcysteinepeptidases.