内分泌与激素

CAS号：851983-85-2

品名：Galeterone(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol

中文别名：Galeterone

英文别名：(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol

分子式：C26H32N2O

分子量：388.545

精确质量：388.251

Psa：38.05

UNII号：WA33E149SW

密度：

简介：Galeterone(TOK-001orVN/124-1)isanovelsteroidalantiandrogenunderdevelopmentbyTokaiPharmaceuticalsforthetreatmentofprostatecancer.Itpossessesauniquedualmechanismofaction,actingasbothanandrogenreceptorantagonistandaninhibitorofCYP17A1,anenzymerequiredforthebiosynthesisoftheandrogens.Itshowsselectivityfor17,20-lyaseover17-hydroxylase.