细胞周期

CAS号：174671-46-6

品名：5-氟-1,3-二氢-1-羟基-2,1-苯并氧杂硼戊环;Tavaboroletavaborole

中文别名：5-氟-1,3-二氢-1-羟基-2,1-苯并氧杂硼戊环;Tavaborole

英文别名：5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole;onychomycosis;Tavaborole(USAN);UNII-K124A4EUQ3;5-fluoro-1-hydroxy-3H-2,1-benzoxaborole;5-fluoro-1,3-dihydro-2,1-benzoxaborol-1-ol;2,1-Benzoxaborole,5-fluoro-1,3-dihydro-1-hydroxy;Tavaborole;1,3-dihydro-5-fluoro-1-hydroxy-2,1-benzoxaborole;5-fluoro-3H-benzo[c][1,2]oxaborol-1-ol;AN2690;5-fluorobenzo[c][1,2]oxaborol-1(3H)-ol;

分子式：C7H6BFO2

分子量：151.931

精确质量：152.044

Psa：29.46

UNII号：K124A4EUQ3

密度：1.288 g/cm3

沸点：230.831ºC at 760 mmHg

闪点：93.404ºC

简介：Tavaborole(AN2690,tradenameKerydin)isatopicalantifungalmedicationforthetreatmentofonychomycosis,afungalinfectionofthenailandnailbed.TavaborolebeganitsPhase3trialsinDecember2010andwasapprovedinJuly2014.Tavaboroleinhibitsanessentialfungalenzyme,leucyl-tRNAsynthetase,thatisrequiredforproteinsynthesis.Theinhibitionofproteinsynthesisleadstoterminationofcellgrowthandthencelldeath,eliminatingthefungalinfection.