干细胞与Wnt信号

CAS号：1373615-35-0

品名：1-[4-(5'-氯-3,5-二甲基[2,4'-联吡啶]-2'-基)-1-哌嗪基]-3-(甲基磺酰基)-1-丙酮1-[4-[5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl]piperazin-1-yl]-3-methylsulfonylpropan-1-one

中文别名：1-[4-(5'-氯-3,5-二甲基[2,4'-联吡啶]-2'-基)-1-哌嗪基]-3-(甲基磺酰基)-1-丙酮

英文别名：1-(4-(5'-chloro-3,5-dimethyl-2,4'-bipyridin-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one;1-(4-(5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one;CS-1206;QC-1145;

分子式：C20H25ClN4O3S

分子量：436.956

精确质量：436.134

Psa：91.85

密度：1.3±0.1g/cm3

沸点：686.0±55.0°Cat760mmHg

闪点：368.7±31.5°C

折射率：1.590

储存条件：roomtemp

蒸汽压：0.0±2.1mmHgat25°C

简介：PF-5274857isapotentandselectiveSmoothened(Smo)antagonist,inhibitsHedgehog(Hh)signaling,respectively,andcanpenetratetheblood–brainbarrier.

干细胞与Wnt信号

CAS号：284028-89-3

品名：3,5,7,8-四氢-2-[4-(三氟甲基)苯基]-4H-噻喃并[4,3-d]嘧啶-4-酮2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one

中文别名：3,5,7,8-四氢-2-[4-(三氟甲基)苯基]-4H-噻喃并[4,3-d]嘧啶-4-酮

英文别名：XAV939,XAV-939;XAV939;3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one;NVP-XAV939;

分子式：C14H11F3N2OS

分子量：312.31

精确质量：312.054

Psa：71.31

MDL号：MFCD16879017

密度：1.5 g/cm3

沸点：429.3ºC at 760 mmHg

闪点：213.4ºC

安全说明：S26-S45

危险类别码：R25; R36

危险品运输编码：UN 2811

简介：Atankyrase(TNKS)inhibitorthatantagonizesWntsignalingviastimulationofβ-catenindegradationandstabilizationofaxin.XAV939inhibitsproliferationoftheμ-catenin-dependentcoloncarcinomacelllineDLD-1.

干细胞与Wnt信号

CAS号：1127442-82-3

品名：rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-六氢-1,3-二氧代-4,7-甲桥-2H-异吲哚-2-基]-N-8-喹啉基苯甲酰胺IWR-1-endo

中文别名：rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-六氢-1,3-二氧代-4,7-甲桥-2H-异吲哚-2-基]-N-8-喹啉基苯甲酰胺

英文别名：IWR-1-endo

分子式：C25H19N3O3

分子量：409.437

精确质量：409.143

Psa：79.37

密度：1.4±0.1g/cm3

沸点：643.9±55.0°Cat760mmHg

闪点：343.2±31.5°C

折射率：1.741

储存条件：StoreatRT

蒸汽压：0.0±1.9mmHgat25°C

简介：IWR-3actasinhibitorsofWntresponse.ItappearthatIWRcompoundsinducestabilizationofAxinproteinsviaadirectinteraction,whichisapartoftheb-catenindestructioncomplex(consistsofApc,Axin,Ck1andGsk3b).\nSuchcompoundsmaybeusedinthetreatmentofWntproteinsignaling-relateddiseasesandconditionssuchascancer,degenerativediseases,typeIIdiabetesandosteopetrosis.

干细胞与Wnt信号

CAS号：780757-88-2

品名：2,3-二氢-1,4-苯并恶嗪2H-PYRAZINO[1,2-A]PYRIMIDINE-1(6H)-CARBOXAMIDE,HEXAHYDRO-6-[(4-HYDROXYPHENYL)METHYL]-8-(1-NAPHTHALENYLMETHYL)-4,7-DIOXO-N-(PHENYLMETHYL)-,(6R,9AR)-REL-

中文别名：(6S,9AS)-6-(4-HYDROXYBENZYL)-N-BENZYL-8-(NAPHTHALEN-1-YLMETHYL)-4,7-DIOXO-HEXAHYDRO-2H-PYRAZINO[1,2-A]PYRIMIDINE-1(6H)-CARBOXAMIDE;(6S,9as)-n-苄基-6-(4-羟基苄基)-8-(萘-1-甲基)-4,7-二氧代八氢-1H-吡嗪o[1,2-a]嘧啶-1-羧酰胺;香紫苏醇.硬尾醇;ICG001;(6R,9AR)-REL-六氢-6-[(4-羟基苯基)甲基]-8-(1-萘基甲基)-4,7-二氧代-N-(苯基甲基)-2H-吡嗪并[1,2-A]嘧啶-1(6H)-甲酰胺;

英文别名：(6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylMethyl);(6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxooctahydro-1H-pyrazino[1,2-a]pyrimidine-1-carboxamide;(6S,9aS)-6-(4-hydroxybenzyl)-N-benzyl-8-(naphthalen-1-ylmethyl)-4,7-dioxo-hexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide;(S,S)-ICG001;(6R,9aR)-rel-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide;(6S,9AS)-6-(4-HYDROXYBENZYL)-8-NAPHTHALEN-1-YLMETHYL-4,7-DIOXO-HEXAHYDRO-PYRAZINO[1,2-A]PYRIMIDINE-1-CARBOXYLICACIDBENZYLAMIDE;(6S,9aS)-rel-Hexahydro-6-[(4-hydroxyphenyl)Methyl]-8-(1-naphthalenylMethyl)-4,7-dioxo-N-(phenylMethyl)-2H-pyrazino[1,2-a]pyriMidine-1(6H)-carboxaMide;

分子式：C33H32N4O4

分子量：548.632

精确质量：548.242

Psa：93.19

密度：1.37g/cm3

沸点：895.6ºC at 760 mmHg

熔点：133-134ºC

闪点：495.4ºC

折射率：1.722

干细胞与Wnt信号

CAS号：879085-55-9

品名：2-氯-N-[4-氯-3-(2-吡啶基)苯基]-4-(甲磺酰基)苯甲酰胺vismodegib

中文别名：维莫德吉;2-氯-n-[4-氯-3-(2-吡啶)苯基]-4-(甲基磺酰基)苯甲酰胺;

英文别名：Vismodegib;2-Chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide;

分子式：C19H14Cl2N2O3S

分子量：421.297

精确质量：420.01

Psa：84.51

MDL号：MFCD12407408

密度：1.44

沸点：561.6ºC at 760 mmHg

闪点：293.4ºC

折射率：1.64

海关编码：2933399090

简介：TargetstheHedgehog(Hh)pathway.InhibitionoftheHhsignalingmaybeeffectiveinthetreatmentandpreventionofmanytypesofhumancancers.