膜转运/离子通道

CAS号：856925-71-8

品名：(-)-Blebbistatin(S)-(-)-Blebbistatin

中文别名：(-)-Blebbistatin

英文别名：(3aS)-3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one;

分子式：C18H13N2O2

分子量：289.308

精确质量：289.098

Psa：52.9

MDL号：MFCD08460907

密度：

熔点：210-212ºC

储存条件：Desiccate at +4ºC

信号词：Warning

危险性防范说明：P261; P280; P305 + P351 + P338

危险标志：GHS07

危险性描述：H302; H312; H315; H317; H319; H332; H335

简介：BlebbistatinblockedmyosinII-dependentcellprocesses.Itblockscellblebbingrapidlyandreversibly.Blebbistatinalsorapidlydisrupteddirectedcellmigrationandcytokinesisinvertebratecell.Blebbistatinblocksbothblebbingandcytokinesisat50-100µM.\n[Blebbistatin:a]D=-103(c=1.21CHCl3)\n(-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one\n\nBlebbistatinisaselectiveinhibitorofnonmusclemyosinII;Blebbistatininhibitscontractionofthecleavagefurrowwithoutdisruptingmitosisorcontractileringassembly.Blebbistatinrapidlyandreversiblyblockscellblebbing,anddisruptsdirectedcellmigrationandcytokinesisinvertebratecells.