细胞信号和神经生物学

CAS号：19545-26-7

品名：渥曼青霉素wortmannin

中文别名：奥特曼宁;抗生素SL-2052;

英文别名：Wartmannin;SL-2052;AntibioticSL-2052;

分子式：C23H24O8

分子量：428.432

精确质量：428.147

Psa：109.11

RTECS号：CB9641000

BRN号：67676

EINECS号：214-538-0

MDL号：MFCD00133927

PubChem号：24278777

外观与性状：白色固体

密度：1.39 g/cm3

沸点：615.6ºC at 760 mmHg

熔点：234-240ºC

闪点：326.1ºC

折射率：1.591

储存条件：2-8ºC

蒸汽压：4.35E-15mmHg at 25°C

安全说明：28-36/37-45

危险类别码：R26/27/28

危险品运输编码：UN 3462

危险品标志：T+

简介：Wortmannin,asteroidmetaboliteofthefungiPenicilliumfuniculosum,Talaromyceswortmannii,isanon-specific,covalentinhibitorofphosphoinositide3-kinases(PI3Ks).Ithasaninvitroinhibitoryconcentration(IC50)ofaround5nM,makingitamorepotentinhibitorthanLY294002,anothercommonlyusedPI3Kinhibitor.ItdisplaysasimilarpotencyinvitrofortheclassI,II,andIIIPI3KmembersalthoughitcanalsoinhibitotherPI3K-relatedenzymessuchasmTOR,DNA-PKcs,somephosphatidylinositol4-kinases,myosinlightchainkinase(MLCK)andmitogen-activatedproteinkinase(MAPK)athighconcentrations,Wortmanninhasalsobeenreportedtoinhibitmembersofthepolo-likekinasefamilywithIC50inthesamerangeasforPI3K.Thehalf-lifeofwortmanninintissuecultureisabout10minutesduetothepresenceofthehighlyreactiveC20carbonthatisalsoresponsibleforitsabilitytocovalentlyinactivatePI3K.WortmanninisacommonlyusedcellbiologyreagentthathasbeenusedpreviouslyinresearchtoinhibitDNArepair,receptor-mediatedendocytosisandcellproliferation.

细胞信号和神经生物学

CAS号：518-75-2

品名：桔霉素Citrinin

中文别名：桔青霉素;橘青霉素;橘霉素;

英文别名：(-)-Citrinin;3H-2-Benzopyran-7-carboxylicacid,4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-,(3R-trans)-;Citriain;Cytrinine;(3R,4S)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylicacid;CITRININ;(3S,4R)-8-Hydroxy-3,4,5-trimethyl-6-oxo-4,6-dihydro-3H-2-benzopyran-7-carboxylicacid;BRN0088597;3H-2-Benzopyran-7-carboxylicacid,4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-,(3S,4R)-;4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylicacid;(3R,4S)-4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylicacid;NSC186;EINECS208-257-2;UNII-3S697X6SNZ;(3r-trans)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-isochromene-7-carboxylicacid;

分子式：C13H14O5

分子量：250.247

精确质量：250.084

Psa：83.83

RTECS号：DJ2275000

UNII号：3S697X6SNZ

密度：1.37g/cm3

沸点：440.6ºC at 760mmHg

熔点：175°C (dec.)

闪点：170.2ºC

折射率：1.595

储存条件：库房低温,通风,干燥,与食品原料分开存放

安全说明：S26; S36/37/39; S45

危险类别码：R23/24/25; R40; R36/37/38

WGK Germany：3

危险品运输编码：UN 3462 6.1/PG 3

危险类别：6.1(a)

包装等级：II

危险品标志：T

简介：Citrininisamycotoxinwhichisoftenfoundinfood.Itisasecondarymetaboliteproducedbyfungithatcontaminatelong-storedfoodanditcausesdifferenttoxiceffects,likenephrotoxic,hepatotoxicandcytotoxiceffects.Citrininismainlyfoundinstoredgrains,butsometimesalsoinfruitsandotherplantproducts.

用途：1.微生物源杀虫杀螨剂,作用方式与阿维菌素一样,但桔霉素杀虫谱较窄。主要用于果树(如柑橘等)防治各种害螨,对棉叶螨和橘全爪螨高效,但对卵的活性较差。推荐防治螨类使用剂量为5.6～28g/hm2,制剂中加入矿物油能增加渗透性,提高对螨卵的杀卵活性。