细胞信号和神经生物学
CAS号：24345-16-2
品名：蜂针液明肽Apamin
中文别名：蜂毒明肽;CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2(DISULFIDEBRIDGE:CYS1-CYS11,CYS3-CYS15);
英文别名：apamine;CNCKAPETALCARRCQQH-NH2;M.W.2027.34C79H131N31O24S4;APAMIN,BEEVENOM;APAMINFROMBEEVENOM;APAMINFROMHONEYBEEVENOM;
分子式：C79H131N31O24S4
分子量：2027.34
精确质量：2025.89
Psa：1021.52
RTECS号：CD6899900
EINECS号：246-182-7
MDL号：MFCD00167944
PubChem号：24890526
密度：
折射率：1.724
储存条件：库房通风低温干燥,与食品原料分开存放
安全说明：S22-S24/25
WGK Germany：3
危险品运输编码：UN 2811
危险类别：6.1(b)
包装等级：III
简介：Apaminisan18aminoacidpeptideneurotoxinfoundinapitoxin(beevenom).Drybeevenomconsistsof2-3%ofapamin.ApaminselectivelyblocksSKchannels,atypeofCa2+-activatedK+channelexpressedinthecentralnervoussystem.Toxicityiscausedbyonlyafewaminoacids,thesearecysteine1,lysine4,arginine13,arginine14andhistidine18.TheseaminoacidsareinvolvedinthebindingofapamintotheCa2+-activatedK+channel.DuetoitsspecificityforSKchannels,apaminisusedasadruginbiomedicalresearchtostudytheelectricalpropertiesofSKchannelsandtheirroleintheafterhyperpolarizationsoccurringimmediatelyfollowinganactionpotential.
