沙芬戈 L-THREO-DIHYDROSPHINGOSINE 50mg

CAS号：15639-50-6

品名：沙芬戈L-threo-Dihydrosphingosine

中文别名：L-苏式-二氢神经鞘氨醇;

英文别名：L-THREO-DIHYDROSPHINGOSINE;L-threo-dihydrosphingosine;L-threosphinganine,2S,3S)L-threo-2-amino-1,3-octadecanediol;

分子式：C18H39NO2

分子量：301.508

精确质量：301.298

Psa：66.48

MDL号：MFCD00792847

密度：0.927 g/cm3

沸点：446.2ºC at 760 mmHg

闪点：223.7ºC

折射率：1.477

储存条件：-20ºC

蒸汽压：7.75E-10mmHg at 25°C

海关编码：2922199090

简介：Safingolisalyso-sphingolipidproteinkinaseinhibitor.IthasthemolecularformulaC18H39NO2andisacolorlesssolid.Medicinally,safingolhasdemonstratedpromisinganticancerpotentialasamodulatorofmulti-drugresistanceandasaninducerofnecrosis.Theadministrationofsafingolalonehasnotbeenshowntoexertasignificanteffectontumorcellgrowth.However,preclinicalandclinicalstudieshaveshownthatcombiningsafingolwithconventionalchemotherapyagentssuchasfenretinide,vinblastine,irinotecanandmitomycinCcandramaticallypotentiatetheirantitumoreffects.CurrentlyinPhaseIclinicaltrials,itisbelievedtobesafetoco-administerwithcisplatin.