微生物Microbiology
CAS号：869901-69-9
品名：(6S)-2-[(3-氯-4-氟苯基)甲基]-8-乙基-1,2,6,7,8,9-六氢-10-羟基-N,6-二甲基-1,9-二氧代吡嗪并[1',2':1,5]吡咯并[2,3-d]哒嗪-4-甲酰胺(6S)-2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-6,7-dihydropyrazino[5,6]pyrrolo[1,3-b]pyridazine-4-carboxamide
中文别名：(6S)-2-[(3-氯-4-氟苯基)甲基]-8-乙基-1,2,6,7,8,9-六氢-10-羟基-N,6-二甲基-1,9-二氧代吡嗪并[1',2':1,5]吡咯并[2,3-d]哒嗪-4-甲酰胺
英文别名：ZZX;MK-2048;
分子式：C21H21ClFN5O4
分子量：461.874
精确质量：461.127
Psa：109.46
UNII号：LJ8U884TM5
密度：
简介：MK-2048representsaprototypesecondgenerationintegrasestrandtransferinhibitor(INSTI),itwasdevelopedwiththegoalofretainingactivityagainstvirusescontainingmutationsassiciatedwithresistanceoffirst-generationINSTIs,raltegravir.MK-2048exhibitsinhibitoryactivitytowardsHIVintegraseandtowardsHIVreplication.ItisfourtimesmoreeffectiveininhibitingHIVenzymeintegrasethanthefirstgenerationinhibitor,raltegravir.
