内分泌与激素
CAS号：851983-85-2
品名：Galeterone(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol
中文别名：Galeterone
英文别名：(3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol
分子式：C26H32N2O
分子量：388.545
精确质量：388.251
Psa：38.05
UNII号：WA33E149SW
密度：
简介：Galeterone(TOK-001orVN/124-1)isanovelsteroidalantiandrogenunderdevelopmentbyTokaiPharmaceuticalsforthetreatmentofprostatecancer.Itpossessesauniquedualmechanismofaction,actingasbothanandrogenreceptorantagonistandaninhibitorofCYP17A1,anenzymerequiredforthebiosynthesisoftheandrogens.Itshowsselectivityfor17,20-lyaseover17-hydroxylase.
