N’1,N’3-二甲基-N’1,N’3-二(苯基硫代羰基... N’1,N’3-Dimethyl-N’1,N’3-di(... 0.1g

CAS号：488832-69-5

品名：伊利司莫elesclomol

中文别名：丙二酸-1,3-二[2-甲基-2-(苯基硫酮甲基)酰肼];

英文别名：STA-4783;1-N',3-N'-bis(benzenecarbonothioyl)-1-N',3-N'-dimethylpropanedihydrazide;Elesclomol;N-malonyl-bis(N'-thiobenzoyl-N'-methylhydrazide);

分子式：C19H20N4O2S2

分子量：400.518

精确质量：400.103

Psa：128.86

MDL号：MFCD12911784

密度：1.313

折射率：1.667

简介：Elesclomol(INN,codenamedSTA-4783)isadrugthattriggersapoptosis(programmedcelldeath)incancercells.ItisbeingdevelopedbySyntaPharmaceuticalsandGlaxoSmithKlineasachemotherapyadjuvant,andhasreceivedbothfasttrackandorphandrugstatusfromtheU.S.FoodandDrugAdministrationforthetreatmentofmetastaticmelanoma.SyntaPharmaceuticalsannouncedonFebruary26,2009thesuspensionofallclinicaltrialsinvolvingElesclomolduetosafetyconcerns.InMarch2010,SyntaannouncedthattheFDAhadapprovedresumingclinicaldevelopmentofelesclomol,andthattheyexpectedtoinitiateoneormoreclinicaltrialsforelesclomolinthesecondhalfoftheyear.