(R)-(+)-2-甲基-CBS-噁唑硼烷溶液 (R)-(+)-2-Methyl-CBS-oxazabo... 5ml

CAS号：112022-83-0

品名：(R)-2-甲基-CBS-噁唑硼烷(R)-2-Methyl-CBS-oxazaborolidine

中文别名：(R)-(+)-甲基-CBS-恶唑硼烷;(R)-3-甲基-CBS-氧杂硼啶;(R)-(+)-2-甲基-CBS-噁唑硼烷;(R)-2-甲基-CBS-恶唑硼烷;(R)-5,5-联苯-2-甲基-3,4-丙醇-1,3,2-恶唑硼烷;

英文别名：(R)-5,5-Diphenyl-2-methyl-3,4-propano-1,3,2-oxazaborolidine;(R)-3,3-Diphenyl-1-methyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole;(R)-1-methyl-3,3-diphenylhexahydropyrrolo[1,2-c][1,3,2]oxazaborole;(R)-(+)-2-Methyl-CBS-oxazaborolidine;(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole;1H,3H-Pyrrolo[1,2-c][1,3,2]oxazaborole,tetrahydro-1-methyl-3,3-diphenyl-,(3aR)-;

分子式：C18H20BNO

分子量：277.169

精确质量：277.164

Psa：12.47

BRN号：9059874

EINECS号：000-000-0

MDL号：MFCD00078440

PubChem号：24883644

外观与性状：白色至淡黄色晶体粉末

密度：0.925

沸点：377.5ºC at 760 mmHg

熔点：85-95ºC

闪点：182.1ºC

储存条件：2-8ºC

蒸汽压：0mmHg at 25°C

安全说明：S16-S25-S29-S33

危险类别码：R11; R20

海关编码：2934999090

危险品运输编码：UN 1294 3

包装等级：II

危险品标志：F; Xi; Xn

简介：(R)-2-Methyl-CBS-oxazaborolidineisanorganoboroncatalystthatisusedinorganicsynthesis.Thiscatalyst,developedbyItsunoandEliasJamesCorey,isgeneratedbyheating(R)-(+)-2-(diphenylhydroxymethyl)pyrrolidinealongwithtrimethylboroxineormethylboronicacid.Itisanexcellenttoolforthesynthesisofalcoholsinhighenantiomericratio.Generally,2-10mol%ofthiscatalystisusedalongwithborane-tetrahydrofuran(THF),borane-dimethylsulfide,borane-N,N-diethylaniline,ordiboraneastheboranesource.Enantioselectivereductionusingchiraloxazaborolidinecatalystshasbeenusedinthesynthesisofcommercialdrugssuchasezetimibeandaprepitant.