抗生素
CAS号：149-29-1
品名：棒曲霉素patulin
中文别名：开放毒霉素;4-羟基-4H-呋[3,2-c]吡喃-2(6H)-酮;
英文别名：Leucopin;Clavatin;Expansine;4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one,PAT;Patuline;Clavacin;Gigantin;Claviform;Expansin;Clairformin;4-hydroxy-4,6-dihydrofuro[3,2-c]pyran-2-one;4H-Furo[3,2-c]pyran-2(6H)-one,4-hydroxy-;
分子式：C7H6O4
分子量：154.12
精确质量：154.027
Psa：55.76
RTECS号：LV2625000
BRN号：149675
EINECS号：205-735-2
MDL号：MFCD00005858
PubChem号：24898227
外观与性状：白色结晶
密度：1.52 g/cm3
沸点：513.7ºC at 760 mmHg
熔点：108-111 °C
闪点：226.8ºC
折射率：1.603
储存条件：库房低温,通风,干燥,与食品原料分开存放
蒸汽压：1.06E-12mmHg at 25°C
安全说明：S45-S36/37
危险类别码：R25
WGK Germany：3
危险品运输编码：UN 3462 6.1/PG 2
危险类别：6.1(a)
包装等级：I
危险品标志：T; Xn
简介：Patulinisamycotoxinproducedbyavarietyofmolds,inparticular,AspergillusandPenicilliumandByssochlamys.Mostcommonlyfoundinrottingapples,ingeneraltheamountofpatulininappleproductsisviewedasameasureofthequalityoftheapplesusedinproduction.Inaddition,patulinhasbeenfoundinotherfoodssuchasgrains,fruits,andvegetables.Whilenotconsideredaparticularlypotenttoxin,anumberofstudieshaveshownpatulintobegenotoxic,whichhasledsometotheorizethatitmaybeacarcinogen,althoughanimalstudieshaveremainedinconclusive.Patulinhasshownantimicrobialpropertiesagainstsomemicroorganisms.Severalcountrieshaveinstitutedpatulinrestrictionsinappleproducts.TheWorldHealthOrganizationrecommendsamaximumconcentrationof50µg/Linapplejuice.IntheEuropeanUnion,thelimitissetto50microgramsperkilogram(µg/kg)inbothapplejuiceandcider,andtohalfofthatconcentration,25µg/kg,insolidappleproductsand10µg/kginproductsforinfantsandyoungchildren.Theselimitscameintoforceon1November2003.
用途：广谱抗细菌、抗真菌抗生素，并有抗肿瘤作用。对猫有利尿作用。由于对人、动物(小鼠LD50静脉注射25～35mg/kg)和植物(1μg/
