S-亚硝基谷胱甘肽 S-Nitrosoglutathione 1g

CAS号：57564-91-7

品名：N-(N-L-γ-谷氨酰基-S-亚硝基-L-半胱氨酰----甘氨酸S-nitrosoglutathione

中文别名：亚硝基谷胱甘肽;S-亚硝基-L-谷胱甘肽;S-亚硝基谷胱甘肽;N-(N-L-Γ-谷氨酰基-S-亚硝基-L-半胱氨酰甘氨酸;

英文别名：S-Nitroso-L-glutathione;S-NITROSOGLUTATHIONE;

分子式：C10H16N4O7S

分子量：336.322

精确质量：336.074

Psa：213.55

RTECS号：MC0558000

MDL号：MFCD00214341

外观与性状：粉红色粉末

密度：1.68 g/cm3

熔点：&>170ºC (dec.)

储存条件：-20ºC

安全说明：S26-S36

危险类别码：R36/37/38

WGK Germany：3

海关编码：2930909090

危险品标志：Xi

信号词：Warning

危险性防范说明：P261; P305 + P351 + P338

危险标志：GHS07

危险性描述：H315; H319; H335

简介：S-Nitrosoglutathione(GSNO)isanendogenousS-nitrosothiol(SNO)thatplaysacriticalroleinnitricoxide(NO)signalingandisasourceofbioavailableNO.NOcoexistsincellswithSNOsthatserveasendogenousNOcarriersanddonors.SNOsspontaneouslyreleaseNOatdifferentratesandcanbepowerfulterminatorsoffreeradicalchainpropagationreactions,byreactingdirectlywithROO•radicals,yieldingnitroderivativesasendproducts.NOisgeneratedintracellularlybythenitricoxidesynthase(NOS)familyofenzymes:nNOS,eNOSandiNOSwhiletheinvivosourceofmanyoftheSNOsisunknown.Inoxygenatedbuffers,however,formationofSNOsisduetooxidationofNOtodinitrogentrioxide(N2O3).SomeevidencesuggeststhatbothexogenousNOandendogenouslyderivedNOfromnitricoxidesynthasescanreactwithglutathionetoformGSNO.