神经信号
CAS号：193611-72-2
品名：BRL15572盐酸盐BRL15572hydrochloride,3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanolhydrochloride
中文别名：四氢罂粟碱盐酸盐;
英文别名：BRL15572hydrochloride,3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanolhydrochloride
分子式：C25H28Cl2N2O
分子量：443.409
精确质量：442.158
Psa：26.71
MDL号：MFCD02684402
密度：
沸点：580.7ºC at 760 mmHg
闪点：305ºC
蒸汽压：2.51E-14mmHg at 25°C
简介：BRL-15,572isadrugwhichactsasaselectiveantagonistfortheserotoninreceptorsubtype5-HT1D,witharound60xselectivityoverotherrelatedreceptors.The5-HT1Dreceptorhasaverysimilarpharmacologytothecloselyrelated5-HT1Breceptor,andmostolderligandsforthesereceptorsbindtobothsubtypeswithapproximatelyequalaffinity,sodevelopmentofcompoundssuchasBRL-15572whichareabletoselectivelyblockthe5-HT1Dsubtypewhileleaving5-HT1Bunaffected,havebeenasignificantadvancewhichhashelpedscientistsinresearchingthefunctionoftheseserotoninreceptorsubtypes.Onefunctionofthe5-HT1Dreceptorthisresearchhasrevealedisitsroleinmodulatingreleaseoftheneurotransmitterglutamateinthebrain,aswellasfunctionsinregulationofcerebralbloodpressurewhichareimportantinthepathogenesisofmigraineheadaches.
