铂
CAS号：41575-94-4
品名：卡铂carboplatin
中文别名：顺-二氨-1,1-环丁烷基二羧酸铂;碳铂;顺-二氨-1,1-环丁烷基二羟酸铂;顺羧酸铂;(SP-4-2)-二氨[1,1-环丁烷二羧络(2-)-O,O']铂;顺式-1,1-环丁烷二羧酸二氨铂;硫酸博莱霉素;卡铂CARBOPLATIN;卡波铂;
英文别名：cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II);cis-Diammine(1,1-cyclobutanedicarboxylato)platinum;cis-diammine(cyclobutane-1,1-dicarboxylato)platinum(II);(SP-4-2)-diammine(1,1-cyclobutanedicarboxylato)platinum(II);cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II);Carboplatin;diammine(cyclobutane-1,1-dicarboxylato)platinum(II);CARBOPLATINUM;PARAPLATIN;PARAPLATIN(R);CARBONPLATIN;cis-diammmine(1,1-cyclobutanedicarboxylato)platinum(II);JM-8;cbdca;
分子式：C6H12N2O4Pt
分子量：371.248
精确质量：371.044
Psa：59.08
UNII号：BG3F62OND5
外观与性状：白色结晶粉末
密度：
沸点：366.4ºCat 760 mmHg
熔点：228-230ºC
闪点：189.6ºC
稳定性：Stable. Incompatible with strong oxidizing agents.
储存条件：Store at RT
安全说明：S53-S22-S26-S36/37/39-S45
危险类别码：R46; R61; R20/21; R42/43
WGK Germany：3
海关编码：2843900030
危险品运输编码：UN 2811
危险品标志：T
信号词：Danger
危险性防范说明：P201; P261; P280; P308 + P313
危险标志：GHS07, GHS08
危险性描述：H302 + H312 + H332; H317; H334; H340; H360
简介：Carboplatin,soldunderthetradenameParaplatinamongothers,isachemotherapydrugusedagainstsomeformsofcancer(mainlyovariancarcinoma,lung,headandneckcancersaswellasendometrial,esophageal,bladder,breastandcervical;centralnervoussystemorgermcelltumors;osteogenicsarcoma,andaspreparationforastemcellorbonemarrowtransplant).Itwasintroducedinthelate1980sandhassincegainedpopularityinclinicaltreatmentduetoitsvastlyreducedsideeffectscomparedtoitsparentcompoundcisplatin.Cisplatinandcarboplatinbelongtothegroupofplatinum-basedantineoplasticagents,andinteractwithDNAtointerferewithDNArepair.
用途：是第二代铂类抗癌新药，其活性与顺铂相当，生化性质与活性谱也类似，但毒副作用却明显低于顺铂。
