代谢
CAS号：171596-29-5
品名：他达那非Tildenafil
中文别名：西力士;他地那非;
英文别名：Cialis;(6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12atetrahydropyrazino[1',2':1,6]pyrido[3,4b]indole1,4(6H,7H)-dione;(6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]\r\npyrido[3,4-b]indole-1,4-dione;
分子式：C22H19N3O4
分子量：389.404
精确质量：389.138
Psa：74.87
MDL号：MFCD07771966
外观与性状：灰白色水晶般的固体
密度：1.51 g/cm3
沸点：679.1ºC at 760 mmHg
熔点：298-300ºC
闪点：364.5ºC
折射率：1.705
蒸汽压：5.29E-13mmHg at 25°C
简介：TadalafilisaPDE5inhibitormarketedinpillformfortreatingerectiledysfunction(ED)underthenameCialis,andunderthenameAdcircaforthetreatmentofpulmonaryarterialhypertension.InOctober2011theU.S.FoodandDrugAdministration(FDA)approvedCialisfortreatingthesignsandsymptomsofbenignprostatichyperplasia(BPH)aswellasacombinationofBPHanderectiledysfunction(ED)whentheconditionscoincide.ItinitiallywasdevelopedbythebiotechnologycompanyICOS,andthenagaindevelopedandmarketedworld-widebyLillyICOS,LLC,thejointventureofICOSCorporationandEliLillyandCompany.Cialistablets,in2.5mg,5mg,10mg,and20mgdoses,areyellow,film-coated,andalmond-shaped.Theapproveddoseforpulmonaryarterialhypertensionis40mg(two20-mgtablets)oncedaily.
用途：磷酸二酯酶5抑制剂,用于治疗男性勃起功能障碍。
