PI3K/Akt/mTOR
CAS号：1062169-56-5
品名：WYE354;4-[6-[4-[(甲氧羰基)氨基]苯基]-4-(4-吗啉基)-1H-吡唑并[3,4-d]嘧啶-1-基]-1-哌啶羧酸甲酯methyl4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
中文别名：WYE354;4-[6-[4-[(甲氧羰基)氨基]苯基]-4-(4-吗啉基)-1H-吡唑并[3,4-d]嘧啶-1-基]-1-哌啶羧酸甲酯
英文别名：pyrazolopyrimidine,19;WYE354;
分子式：C24H29N7O5
分子量：495.531
精确质量：495.223
Psa：123.94
密度：1.5±0.1g/cm3
沸点：594.2±50.0°Cat760mmHg
闪点：313.2±30.1°C
折射率：1.692
储存条件：-20°C
蒸汽压：0.0±1.7mmHgat25°C
简介：ApyrazolopyrimidinesderivativethatisapotentandATP-competitivemTORinhibitorwithmuchreducedactivityagainstPI3-KαorPI3-Kγ.WYE-354isequallypotentagainstmTORC1andmTORC2activitiesinHEK293immunecomplexkinaseassaysusingS6KandAktastherespectivesubstrate(IC50<200nM;[ATP]=100µM)andeffectivelyblockscellularphosphorylationofS6KonT389andAktonS473bothinculturesandinamurinexenograftmodel,resultinginasignificantsuppressionofPC3MM2-derivedtumorgrowth(by86%onday7;50mg/kg,i.ptwiceperday)invivo.
