抗生素
CAS号：17397-89-6
品名：浅蓝菌素Cerulenin
中文别名：天蓝菌素;变蓝菌素;2,3-环氧-4-氧-7,10-十二碳二烯酰胺;
英文别名：2,3-Epoxy-4-oxo-7,10-dodecadienamide;3S)-2,3-epoxy-4-oxo-7,10-trans;Helicocerin;caeruleinA;(2R,3S)-3-[(4E,7E)-nona-4,7-dienoyl]oxirane-2-carboxamide;trans-dodecadienamide);7,10-Dodecadienamide,2,3-epoxy-4-oxo-,(2R,3S)-;
分子式：C12H17NO3
分子量：223.268
精确质量：223.121
Psa：72.69
RTECS号：JR1670000
BRN号：4140423
EINECS号：241-424-8
MDL号：MFCD00077686
PubChem号：24892323
外观与性状：白色至灰白色粉末
密度：1.134 g/cm3
沸点：456.1ºC at 760 mmHg
熔点：93.5℃
闪点：241.1ºC
折射率：1.529
储存条件：-20ºC
蒸汽压：1.66E-08mmHg at 25°C
危险类别码：R22
危险品标志：Xn
简介：Ceruleninisanantifungalantibioticthatinhibitsfattyacidandsteroidbiosynthesis.Infattyacidsynthesis,ithasbeenreportedtobindinequimolarratiotob-keto-acyl-ACPsynthase,oneofthesevenmoietiesoffattyacidsynthase,blockingtheinteractionofmalonyl-CoA.ItalsohastherelatedactivityofstimulatingfattyacidoxidationthroughtheactivationofCPT1,anotherenzymenormallyinhibitedbymalonyl-CoA.Inhibitioninvolvescovalentthioacylationthatpermanentlyinactivatestheenzymes.ThesetwobehaviorsmayincreasetheavailabilityofenergyintheformofATP,perhapssensedbyAMPK,inthehypothalamus.
