细胞信号和神经生物学
CAS号：19545-26-7
品名：渥曼青霉素wortmannin
中文别名：奥特曼宁;抗生素SL-2052;
英文别名：Wartmannin;SL-2052;AntibioticSL-2052;
分子式：C23H24O8
分子量：428.432
精确质量：428.147
Psa：109.11
RTECS号：CB9641000
BRN号：67676
EINECS号：214-538-0
MDL号：MFCD00133927
PubChem号：24278777
外观与性状：白色固体
密度：1.39 g/cm3
沸点：615.6ºC at 760 mmHg
熔点：234-240ºC
闪点：326.1ºC
折射率：1.591
储存条件：2-8ºC
蒸汽压：4.35E-15mmHg at 25°C
安全说明：28-36/37-45
危险类别码：R26/27/28
危险品运输编码：UN 3462
危险品标志：T+
简介：Wortmannin,asteroidmetaboliteofthefungiPenicilliumfuniculosum,Talaromyceswortmannii,isanon-specific,covalentinhibitorofphosphoinositide3-kinases(PI3Ks).Ithasaninvitroinhibitoryconcentration(IC50)ofaround5nM,makingitamorepotentinhibitorthanLY294002,anothercommonlyusedPI3Kinhibitor.ItdisplaysasimilarpotencyinvitrofortheclassI,II,andIIIPI3KmembersalthoughitcanalsoinhibitotherPI3K-relatedenzymessuchasmTOR,DNA-PKcs,somephosphatidylinositol4-kinases,myosinlightchainkinase(MLCK)andmitogen-activatedproteinkinase(MAPK)athighconcentrations,Wortmanninhasalsobeenreportedtoinhibitmembersofthepolo-likekinasefamilywithIC50inthesamerangeasforPI3K.Thehalf-lifeofwortmanninintissuecultureisabout10minutesduetothepresenceofthehighlyreactiveC20carbonthatisalsoresponsibleforitsabilitytocovalentlyinactivatePI3K.WortmanninisacommonlyusedcellbiologyreagentthathasbeenusedpreviouslyinresearchtoinhibitDNArepair,receptor-mediatedendocytosisandcellproliferation.
