去垢剂
CAS号：14605-22-2
品名：牛磺脱氧胆酸TauroursodeoxycholicAcidDihydrate
中文别名：牛磺熊去氧胆酸;牛磺熊脱氧胆酸;牛磺雄去氧胆酸;牛熊去氧胆酸钠;牛磺酸熊脱氧胆酸;
英文别名：2-[[(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonicacid;TAUROURSODEOXYCHOLICACID;3α,7β-Dihydroxy-5β-cholan-24-oicAcidN-(2-Sulfoethyl)amideDihydrate;Tauroursodeoxycholicaciddihydrate;Tauroursodeoxycholicacidsodiumsalt;Sodiumtauroursodeoxycholate;3α,7β-Dihydroxy-5β-cholan-24-oicacidN-(2-sulfoethyl)amide;
分子式：C26H45NO6S
分子量：499.704
精确质量：499.297
Psa：132.31
RTECS号：KI7372500
MDL号：MFCD00065451
PubChem号：24899875
外观与性状：白色固体
密度：1.216 g/cm3
沸点：496.4ºC at 760mmHg
熔点：173-175°C
闪点：214.2ºC
折射率：46 ° (C=1, EtOH)
安全说明：S22; S24/25
WGK Germany：2
简介：Tauroursodeoxycholicacid(TUDCA)isanambiphilicbileacid.Itisthetaurineconjugateformofursodeoxycholicacid(UDCA).HumansarefoundtohavetraceamountsofTUDCA.However,bearscontainlargeamountsofTUDCAintheirbile;UDCAandconjugatescompriseabout47%ofthebileinAmericanblackbearsandupto76%inAsiaticbears.TUDCAhasbeenusedinancientAsianpharmacopoeiasforitssupposedbeneficialeffects.UDCAisproducedinseveralcountriesforthetreatmentofgallstonesandlivercirrhosis.ItisnotapprovedbytheFoodandDrugAdministration,intheU.S.whileUDCAisapprovedintheUnitedStatesforthetreatmentofprimarybiliarycirrhosisOngoingresearchisfindingTUDCAhasdiminishingapoptoticeffects,helpingwithcardiacfunction,Huntington'sdisease,Parkinson'sDisease,andstroke.Recently,TUDCAhasbeenfoundtohaveprotectiveeffectsintheeye,especiallyconcerningretinaldegenerativedisorders.
