CAS:1135242-13-5
1135242-13-5
CAS号：1135242-13-5
品名：VU0357017盐酸盐ethyl4-[2-[(2-methylbenzoyl)amino]ethylamino]piperidine-1-carboxylate,hydrochloride
中文别名：VU0357017盐酸盐
英文别名：VU0357017Hydrochloride;VU0357017monohydrochloride;ML071hydrochloride;
分子式：C18H28ClN3O3
分子量：369.886
精确质量：369.182
Psa：74.16
MDL号：MFCD17215959
密度：
储存条件：2-8℃
简介：VU0357017isasubtype-selectiveM1muscarinicacetylcholineallostericagonist.VU0357017hasapotencyof200nMandAchmaxof81%andhadnoactivityatM2-M5uptothehighestconcentrationstestedandalsohadlittleornodetectableantagonistactivityatanyothermAChRsubtypeatconcentrationsover2ordersofmagnitudehigherthanthoserequiredtoactivateM1oractivityatalargepanelofGPCRs,ionchannels,andtransporters.Incontrast,TBPBinhibitedresponsestoAChateachoftheothermAChRsubtypes.VU0357017wasactiveinreversingcognitivedeficitsinducedbyScopolamineinapreclinicalrodentmodel.
合成
