CAS:147025-53-4
147025-53-4
CAS号：147025-53-4
品名：(8R)-8-丙-2-炔氧基-1-氮杂双环[2.2.2]辛烷(3R)-3-prop-2-ynoxy-1-azabicyclo[2.2.2]octane
中文别名：(8R)-8-丙-2-炔氧基-1-氮杂双环[2.2.2]辛烷
英文别名：WAL2014;Talsaclidine;
分子式：C10H15NO
分子量：165.232
精确质量：165.115
Psa：12.47
UNII号：1O8VSL798T
密度：1.06g/cm3
沸点：251.1ºC at 760mmHg
闪点：73.3ºC
折射率：1.525
储存条件：-20ºC
蒸汽压：0.0208mmHg at 25°C
安全说明：S26
危险类别码：R41
危险品标志：Xi
简介：Talsaclidine(WAL-2014)isanon-selectivemuscarinicacetylcholinereceptoragonistwhichactsasafullagonistattheM1subtype,andasapartialagonistattheM2andM3subtypes.ItwasunderdevelopmentforthetreatmentofAlzheimer'sdiseasebutshowedonlymodestorpoorefficacyinrhesusmonkeysandhumans,respectively,perhapsduetoanarrayofdose-limitingsideeffectsincludingincreasedheartrateandbloodpressure,increasedsalivation,urinaryfrequencyandburninguponurination,increasedlacrimationandnasalsecretion,abnormalaccommodation,heartburn,upsetstomachaswellascramps,nausea,vomitinganddiarrhea,excessivesweatingandpalpitations.
合成
