CAS号:57564-91-7
品名:N-(N-L-γ-谷氨酰基-S-亚硝基-L-半胱氨酰----甘氨酸S-nitrosoglutathione
中文别名:亚硝基谷胱甘肽;S-亚硝基-L-谷胱甘肽;S-亚硝基谷胱甘肽;N-(N-L-Γ-谷氨酰基-S-亚硝基-L-半胱氨酰甘氨酸;
英文别名:S-Nitroso-L-glutathione;S-NITROSOGLUTATHIONE;
分子式:C10H16N4O7S
分子量:336.322
精确质量:336.074
Psa:213.55
RTECS号:MC0558000
MDL号:MFCD00214341
外观与性状:粉红色粉末
密度:1.68 g/cm3
熔点:&>170ºC (dec.)
储存条件:-20ºC
安全说明:S26-S36
危险类别码:R36/37/38
WGK Germany:3
海关编码:2930909090
危险品标志:Xi
信号词:Warning
危险性防范说明:P261; P305 + P351 + P338
危险标志:GHS07
危险性描述:H315; H319; H335
简介:S-Nitrosoglutathione(GSNO)isanendogenousS-nitrosothiol(SNO)thatplaysacriticalroleinnitricoxide(NO)signalingandisasourceofbioavailableNO.NOcoexistsincellswithSNOsthatserveasendogenousNOcarriersanddonors.SNOsspontaneouslyreleaseNOatdifferentratesandcanbepowerfulterminatorsoffreeradicalchainpropagationreactions,byreactingdirectlywithROO•radicals,yieldingnitroderivativesasendproducts.NOisgeneratedintracellularlybythenitricoxidesynthase(NOS)familyofenzymes:nNOS,eNOSandiNOSwhiletheinvivosourceofmanyoftheSNOsisunknown.Inoxygenatedbuffers,however,formationofSNOsisduetooxidationofNOtodinitrogentrioxide(N2O3).SomeevidencesuggeststhatbothexogenousNOandendogenouslyderivedNOfromnitricoxidesynthasescanreactwithglutathionetoformGSNO.
合成