CAS:118779-53-6
118779-53-6
CAS号：118779-53-6
品名：2-[(二苯基甲基)磺酰基]乙酰胺ModafinilSulfone
中文别名：2-[(二苯基甲基)磺酰基]乙酰胺
英文别名：2-(Benzhydrylsulfonyl)acetamide(2-[(Diphenylmethyl)sulfonyl]acetamide;2-benzhydrylsulfonylacetamide;ModafinilRelatedCompoundB;
分子式：C15H15NO3S
分子量：289.35
精确质量：289.077
Psa：85.61
外观与性状：白色固体
密度：1.289g/cm3
沸点：572.6ºC at 760 mmHg
熔点：199-201ºC
闪点：300.1ºC
折射率：1.61
蒸汽压：4.06E-13mmHg at 25°C
简介：Modafinilsulfone(codenameCRL-41056)isanachiral,oxidizedmetaboliteofmodafinil,awakefulness-promotingagent.Itisoneoftwomajorcirculatingmetabolitesofmodafinil,theotherbeingmodafinilacid.Modafinilsulfoneisalsoametaboliteofthemodafinilprodrug,adrafinil.Modafinilsulfoneisalsoametaboliteofarmodafinil,the(R)-(–)-enantiomerofmodafinil,asoxidationtothesulfoneremovesthechiralcenteratthesulfuratom.Modafinilsulfonehasbeendescribedasinactive,andsimilarlytomodafinilacid,doesnotappeartocontributetothewakefulness-promoting/psychostimulanteffectsofmodafinil.However,likemodafinil,modafinilsulfonewasfoundtoshowanticonvulsantpropertiesinanimals,indicatingthatitdoespossesssomebiologicalactivity.
合成
