CAS:103745-39-7
103745-39-7
CAS号：103745-39-7
品名：法舒地尔FASUDIL
中文别名：1-(5-硫代异喹啉)哌嗪二盐酸盐;六氢-1-(5-异喹啉基磺酰基)-1H-1,4-二氮卓;
英文别名：Fasudilum;Fasudilum[inn-latin];H-1077dihydrochloride;hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine;at877;HA-1077DIHYDROCHLORIDENOVELVASODILATORAGE;1-(5-isoquinolinesulphonyl)-homopiperazine;HA1077,DIHYDROCHLORIDE;1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine,Dihydrochloride;1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE;
分子式：C14H19Cl2N3O2S
分子量：364.291
精确质量：363.058
Psa：70.68
RTECS号：HM4031166
MDL号：MFCD00153805
PubChem号：24895456
外观与性状：白色结晶固体
密度：1.289g/cm3
沸点：506.2ºC at 760mmHg
闪点：259.9ºC
蒸汽压：2.55E-12mmHg at 25°C
WGK Germany：3
海关编码：2933990090
简介：Apotentcalciumantagonistvasodilatorwhichisconsideredtoactbyemployingdifferentmechanismsfromtheusualcalciumchannelblockerssinceitinhibits(1)calciumionophoreA23187inducedcontractioninarterialstripsand(2)phenylephrineinducedcontractionincalciumfreemediasuggestingthatitssiteofactionisintheintracellularspace.AlsoreportedtopotentlyinhibitRho-associatedKinase(ROCKIC50=10.7uM).
用途：钙拮抗剂。用于蛛网膜下出血手术后的血管痉挛，也可用于神经保护、急性脑动脉栓塞、慢性脑梗死和心绞痛。
合成
