CAS:524684-52-4
524684-52-4
CAS号：524684-52-4
品名：普林贝瑞(4Z)-4-(7-ethenyl-5-hydroxy-3H-1,3-benzoxazol-2-ylidene)-2-fluorocyclohexa-2,5-dien-1-one
中文别名：2-(3-氟-4-羟基苯基)-7-乙烯基-1,3-苯并恶唑-5-醇;
英文别名：2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol;SDZ205-557hydrochloride;Prinaberel;UNII-A9C8MNF7CA;BIDD:ER0139;1x7b;ERB041;
分子式：C15H10FNO3
分子量：271.243
精确质量：271.064
Psa：66.49
UNII号：A9C8MNF7CA
密度：1.413
沸点：379.9ºC at 760 mmHg
熔点：250-252ºC
闪点：183.6ºC
信号词：Warning
危险性防范说明：P305 + P351 + P338
危险标志：GHS07
危险性描述：H302; H319
简介：Prinaberel(INN,USAN)(developmentalcodenamesERB-041,WAY-202041)isasynthetic,non-steroidal,andhighlyselectiveagonistoftheERβsubtypeoftheestrogenreceptor.ItisusedinscientificresearchtoelucidatetheroleoftheERβreceptor.StudieshaveindicatedthatselectiveERβagonistslikeprinaberelcouldbeusefulintheclinicaltreatmentofavarietyofmedicalconditionsincludinginflammatoryboweldisease,rheumatoidarthritis,endometriosis,andsepsis.Accordingly,prinabereleitherwasorstillisunderinvestigationbyWyethforthetreatmentofsomeoftheseconditions.
合成
