CAS:298-57-7
298-57-7
CAS号：298-57-7
品名：桂利嗪cinnarizine
中文别名：1-反式-肉桂基-4-二苯基甲基哌嗪;1-二苯甲基-4-(3-苯基-2-丙烯基)哌嗪;肉桂嗪;
英文别名：1-trans-Cinnamyl-4-diphenylmethylpiperazine;Stugeron;Cinnarizine;
分子式：C26H28N2
分子量：368.514
精确质量：368.225
Psa：6.48
RTECS号：TL3430000
UNII号：3DI2E1X18L
外观与性状：白色粉末
密度：1.093g/cm3
沸点：509.2ºC at 760mmHg
熔点：117-120ºC
闪点：229.8ºC
折射率：1.649
储存条件：Refrigerator
蒸汽压：2.35E-10mmHg at 25°C
安全说明：S22; S24/25; S36; S26
危险类别码：R20/22
WGK Germany：2
海关编码：2933599090
危险品标志：Xn
简介：Cinnarizineisamedicationderivativeofpiperazine,andcharacterizedasanantihistamineandacalciumchannelblocker,itisalsoknowntopromotecerebralbloodflow,andsoisusedtotreatcerebralapoplexy,post-traumacerebralsymptoms,andcerebralarteriosclerosis.However,itismorecommonlyprescribedfornauseaandvomitingduetomotionsicknessorothersourcessuchaschemotherapy,vertigo,orMénière'sdisease.CinnarizinewasfirstsynthesizedbyJanssenPharmaceuticain1955.Thenonproprietarynameisderivedfromthecinnamylsubstituentononeofthenitrogenatoms,combinedwiththegenericending\"-rizine\"for\"antihistaminics/cerebral(orperipheral)vasodilators\".ItisnotavailableintheUnitedStatesorCanada.ItismanufacturedandmarketedinBangladeshunderthetradenameSuzaraonbyRephcoPharmaceuticalsLimited.IthasalsobeencitedasoneofthemostuseddrugsforseasicknesswithintheBritishRoyalNavy.
用途：长效多功能的血管收缩拮抗剂，能扩张血管，改善血循环，预防血管脆化，可用于治疗脑血管疾病，对颈性眩晕等引起的头痛，头晕失眠、记忆力减退，偏瘫，肢体麻木无力，言语不清等症也有疗效。
合成
