CAS:3690-10-6
3690-10-6
CAS号：3690-10-6
品名：4-脱氧尿苷zebularine
中文别名：泽布拉林;
英文别名：2(1H)-Pyrimidinone,1-.β.-D-ribofuranosyl-;[14C]-Zebularine;4-Deoyuridine;2(1H)-PyriMidinone,1-b-D-ribofuranosyl;1--D-Ribofuranosyl-2(1H)-pyrimidinone;Zebularine;4-Deoxyuridine;Pyrimidin-2-one-D-Ribofuranoside;
分子式：C9H12N2O5
分子量：228.202
精确质量：228.075
Psa：104.81
UNII号：7A9Y5SX0GY
密度：1.7±0.1g/cm3
沸点：499.0±55.0°Cat760mmHg
熔点：160-162?C
闪点：255.6±31.5°C
折射率：1.697
储存条件：2-8°C
蒸汽压：0.0±2.9mmHgat25°C
简介：Zebularineisanucleosideanalogofcytidine.Itisa\"transitionstateanaloginhibitorofcytidinedeaminasebybindingtotheactivesizeascovalenthydrates.AlsoshowntoinhibitDNAmethylationandtumorgrowthbothinvitroandinvivo.\";InasmallstudyofmicewithadefectiveAdenomatouspolyposiscoligene,oraladministrationofzebularinetomaleshadnoeffectontheoverallmethylationofDNAorthenumberofpolyps,butinfemalestheaveragenumberofpolypswasreducedfrom58to1.Ithasthereforebeensuggestedfordruguseasaprototypeofepigenetictherapyforcancerchemoprevention.
合成
