CAS:179474-81-8
179474-81-8
CAS号：179474-81-8
品名：4-氨基-5-氯-2,3-二氢-N-[1-(3-甲氧基丙基)-4-哌啶基]-7-苯并呋喃甲酰胺Prucalopride
中文别名：7-苯并呋喃甲酰胺,4-氨基-5-氯-2,3-二氢-N-[1-(3-甲氧基丙基)-4-哌啶基];普卡比利;普卡必利;
英文别名：Resolor;4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide;Unii-0A09iuw5tp;
分子式：C18H26ClN3O3
分子量：367.87
精确质量：367.166
Psa：76.82
UNII号：0A09IUW5TP
密度：1.28g/cm3
沸点：481.4ºC at 760mmHg
闪点：244.9ºC
折射率：1.599
蒸汽压：2E-09mmHg at 25°C
简介：Prucalopride(brandnameResolor,developedbyJohnson&JohnsonandlicensedtoMovetis)isadrugactingasaselective,highaffinity5-HT4receptoragonistwhichtargetstheimpairedmotilityassociatedwithchronicconstipation,thusnormalizingbowelmovements.PrucalopridewasapprovedforuseinEuropein2009,inCanada(namedResotran)onDecember7,2011andinIsraelin2014butithasnotbeenapprovedbytheFoodandDrugAdministrationforuseintheUnitedStates.Thedrughasalsobeentestedforthetreatmentofchronicintestinalpseudo-obstruction.
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