CAS:379270-37-8
379270-37-8
CAS号：379270-37-8
品名：替诺福韦艾拉酚胺Tenofoviralafenamide
中文别名：GS7340游离碱;
英文别名：GS-7340;Sp-Tenofovir-phosphonamidate,phenyl,L-alanineisopropylester;TENOFOVIRALAFENAMIDE;propan-2-yl(2S)-2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate;Tenofoviralafenamidefreebase;
分子式：C21H29N6O5P
分子量：476.466
精确质量：476.194
Psa：153.29
UNII号：EL9943AG5J
密度：1.39±0.1g/cm3
沸点：640.4±65.0°Cat760mmHg
闪点：341.1±34.3°C
折射率：1.630
储存条件：室温，干燥
蒸汽压：0.0±1.9mmHgat25°C
简介：Tenofoviralafenamide(INN/USAN,formerlyGS-7340)isanucleotidereversetranscriptaseinhibitorandaprodrugoftenofovir.ItwasdevelopedbyGileadSciencesforuseinthetreatmentofHIVinfectionandchronichepatitisB,andisappliedintheformoftenofoviralafenamidefumarate(TAF).Closelyrelatedtothecommonlyusedreverse-transcriptaseinhibitortenofovirdisoproxil,TAFhasgreaterantiviralactivityandbetterdistributionintolymphoidtissuesthanthatagent.
