CAS:354812-17-2
354812-17-2
CAS号：354812-17-2
品名：4-氨基-[2,3']联噻吩-5-甲酰胺3-amino-5-thiophen-3-ylthiophene-2-carboxamide
中文别名：4-氨基-[2,3']联噻吩-5-甲酰胺
英文别名：4-Amino-[2,3\"]bithiophenyl-5-carboxylicacidamide;SC-514;IKK-2Inhibitor,SC-514;4-amino-2,3'-bithiophene-5-carboxamide;
分子式：C9H8N2OS2
分子量：224.303
精确质量：224.008
Psa：125.59
密度：1.45g/cm3
沸点：399.2ºC at 760 mmHg
闪点：195.2ºC
折射率：1.715
信号词：Danger
危险性防范说明：P301 + P310
危险标志：GHS06
危险性描述：H301
简介：Acell-permeable(thienothienyl)amino-acetamidecompoundthatdisplaysanti-inflammatoryproperties.Actsasapotent,reversible,ATP-competitive,andhighlyselectiveinhibitorofIKK-2(IC50~3-12µMforIKK-2homodimer,IKK-1/IKK-2heterodimer,andIKK-2).Itsspecificityhasbeenconfirmedusingapanelof31otherkinases,includingIKKisoformsIKK-1,IKK-i,andTBK-1(IC50>200µM).ShowntospecificallyblockNF-kB-dependentgeneexpression,butnotMAPkinasepathways,instimulatedsynovialfibroblastsRASF.
NF-kB
