CAS:58970-76-6
58970-76-6
CAS号：58970-76-6
品名：乌苯美司Ubenimex
中文别名：[S-(R*,S*)]-N-(3-氨基-2-羟基-1-氧代-4-苯丁基)-L-亮氨酸;贝他定;N-[(2S,3R)-3-氨基-2-羟基-4-苯丁酰]-L-亮氨酸;N-[(2S,3R)-3-氨基-2-羟基-4-苯基丁酰基]-L-亮氨酸;([2S,3R]-3-氨基-2-羟基-4-苯基丁酰基)-L-亮氨酸;
英文别名：nk421;BENIMEX;BESTATIN;Bestatin,UbeniMex;
分子式：C16H24N2O4
分子量：308.373
精确质量：308.174
Psa：112.65
RTECS号：OH2915000
UNII号：I0J33N5627
外观与性状：白色结晶粉末
密度：1.197 g/cm3
沸点：604.7ºC at 760 mmHg
熔点：245°C (dec.)(lit.)
闪点：319.5ºC
折射率：1.557
稳定性：Stable at normal temperatures and pressures.
储存条件：通风低温干燥,与库房食品原料分开存放
安全说明：S22-S24/25
WGK Germany：3
简介：Ubenimex(INN),alsoknownmorecommonlyasbestatin,isacompetitive,reversibleproteaseinhibitor.Itisaninhibitorofarginylaminopeptidase(aminopeptidaseB),leukotrieneA4hydrolase(azincmetalloproteasethatdisplaysbothepoxidehydrolaseandaminopeptidaseactivities),alanylaminopeptidase(aminopeptidaseM/N),leucyl/cystinylaminopeptidase(oxytocinase/vasopressinase),andmembranedipeptidase(leukotrieneD4hydrolase).Itisbeingstudiedforuseinthetreatmentofacutemyelocyticleukemia.ItisderivedfromStreptomycesolivoreticuli.Ubenimexhasbeenfoundtoinhibittheenzymaticdegradationofoxytocin,vasopressin,enkephalins,andvariousotherpeptidesandcompounds.
用途：急、慢性细胞性白血病等病的辅助治疗
酶抑制剂
